Kinetic Biosystems Inc.

Kbi Biopharma, Inc.

Heath H Herman

Tod M Herman

Robert A Cuneo

Peter J Petrecca

Gerard W Osborne

Arlan K Andrews, Sr

The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.

Methods and compositions for chromatography

The invention comprises novel culture methods and devices in which biocatalysts are substantially immobilized contained, suspended and or incubated in a chamber. At least one injection element provides a fluid flow to a perimeter of the chamber and the fluid force of the fluids flowing into the chamber works with the centripetal force created by rotation of the device to suspend the cells within the chamber, promote cell growth and/or clean the fluid as it passes thru the suspended biocatalyst.

Biocatalyst chamber encapsulation system for bioremediation and fermentation

The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized in an open chamber defined by two rotating disks. The fluid force of nutrient fluids flowing into the chamber opposes the centripetal force created by rotation of the device to suspend the cells within the chamber and promote cell growth. Use of an open chamber increases the capacity of the device to produce the desired cellular products.

Methods and devices for remediation and fermentation

Abstract of the Invention The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces. One embodiment of the apparatus comprises a cruciform design. Commercial applications of the apparatus include efficient isolation of metals from ores and removal of gases.

The present invention comprises a novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces.

Centrifugal fermentation process

The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of articles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.

The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of particles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.

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Tucker, GA, United States of America

Heath H Herman