Future Medicine Co., Ltd.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Board of Trustees, Ewha Womans University

Fm Therapeutics Co., Ltd.

Hea Ok Kim

Mi Ra Yu

Kenneth Alan Jacobson

Lak Shin Jeong

Chong Woo Park

Sang Koo Lee

Hee Woo Lee

Chong-Woo Park

Bo Mi Park

Hyung Ryong Moon

Seung Ah Choe

Kenneth A Jacobson

A pharmaceutical composition for preventing or treating eye diseases and an oral administration agent for preventing or treating eye diseases are provided, wherein the pharmaceutical composition for preventing or treating eye diseases includes the compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.

Pharmaceutical composition for preventing and treating glaucoma, containing adenosine derivative

A pharmaceutical composition for preventing or treating diabetic nephropathy is provided. According to the present invention, a pharmaceutical composition for preventing or treating diabetic nephropathy comprises an adenosine derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient.

Pharmaceutical composition for preventing and treating diabetic nephropaphy including adenosine derivative

A pharmaceutical composition for preventing or treating eye diseases and an oral administration agent for preventing or treating eye diseases are provided. The pharmaceutical composition for preventing or treating eye diseases comprises the compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.

Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for Aadenosine receptors and act as Aadenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient

Disclosed are purine nucleoside compounds that are selective to Aadenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; Ris hydrogen, alkyl, benzyl, halobenzyl, or phenylalkyl; Ris hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio, or thio; Rand R' are hydrogen, hydroxyalkyl, alkoxycarbonyl, or alkylaminocarbonyl, whereas Rand R&#x2032; do not have identical substituents simultaneously; and Ris hydrogen or alkyl. Also disclosed are a pharmaceutical composition comprising a compound of formula (I), an isomer, or its pharmacologically acceptable salt as an active ingredient and a method for preventing or treating various diseases, state, or condition, including asthma, inflammation, cerebral ischemia, heart diseases, and cancer.

Purine nucleosides

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Seoul, South Korea

Hea Ok Kim