Institut National De La Sante Et De La Recherche Medicale

Gencell Sas

He Lu

Claudine Soria

Michel Perricaudet

Patrice Yeh

Jeannette Soria

Thierry Ragot

Yves Legrand

Paule Opolon

Frank Griscelli

Hong Li

Christelle Mabilat

Véronique Trochon

A method of inhibiting angiogenesis or invasion or formation of metastases in a mammal including administering a therapeutically effective amount of an active agent selected from the group consisting of a protein substance including all or part of a disintegrin domain of an adamalysin or a derivative thereof, a nucleic acid molecule including a polynucleotide sequence coding all or part of the disintegrin domain of an adamalysin or a derivative thereof to the mammal.

Method of inhibiting angiogenesis or invasion or formation of metastases

The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.

Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors

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Epinary-sur-Seine, France

He Lu