Cornell University

Social Profit Network

University of Washington

Clinical Research Institute of Montreal

East Carolina University

Institut De Recherches Cliniques De Montreal

Institute De Recherches Cliniques De Montreal

Institute De Recherches Clinques De Montreal

Hazel Szeto

Kesheng Zhao

Peter W Schiller

Hugh Robertson

Alex V Birk

Sunghee Cho

Diane Felsen

Shaoyi Liu

Peter S Rabinovitch

Shaoyl Liu

Dao-Fu Dai

Lorraine J Gudas

Xiaohan Tang

P Darrell Neufer

Ethan J Anderson

Diane Felson

Certain exemplary embodiments are directed to a biologically active composition of matter (and uses thereof) configured for targeted delivery of biotin to mitochondria, the composition comprising a first D-biotin conjugated to a water-soluble, cell-permeable, peptide sequence, wherein the peptide sequence is selected from a polypeptide group with an alternating aromatic-cationic motif.

Methods and compositions for delivery of biotin to mitochondria

The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.

Methods for the prevention or treatment of heart failure

The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.

Method and carrier complexes for delivering molecules to cells

The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.

Methods for prevention and treatment of acute renal injury

The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3 pis the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 2a is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1.

Methods for reducing CD36 expression

The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, and inhibition of apoptosis and necrosis to treat, prevent or ameliorate the symptoms of autoimmune diseases or condition.

Aromatic-cationic peptides and uses of same

The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3 pis the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 3a or 2a is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1; and (f) at least one tyrosine or tryptophan amino acid.

Methods for reducing oxidative damage

Methods for preventing or treating oral cancers, and/or reducing the severity of symptoms of oral cancers are described. The methods comprise administering an effective amount of an aromatic-cationic peptide to a subject in need thereof to normalize expression levels of genes involved in oral carcinogenesis.

Methods for preventing and treating oral cancers

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New York, NY, United States of America

Hazel Szeto