The Johns Hopkins University

Hayden T Ravert

Robert Francis Dannals

Martin Gilbert Pomper

Ronnie Charles Mease

Ying Chen

Igal Madar

Hong Fan

Daniel P Holt

Ursula A Scheffel

James J Frost

Robert F Dannals

Methods, and related compositions, for the improved synthesis of [F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [F]DCFPyL so produced.

Synthesis of the radiolabeled prostate-specific membrane antigen (PSMA) inhibitor [F]DCFPYL

Synthesis of the radiolabeled prostate-specific membrane antigen (PSMA) inhibitor [F]DCFPyL

The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.

Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts

The invention provides a series of lipophilic phosphonium cations (PhCs) labeled withF for non-invasive assessment of &#x394;&#x3a8;m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.

Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts

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Bel Air, MD, United States of America

Hayden T Ravert