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Sunnybrook Research Institute

Haydar Celik

Ergin Atalar

Graham Arnold Wright

Venkat R Swaminathan

Graham A Wright

Described here are systems and methods for visualizing thermal ablation lesions by imaging specific chemical compounds that are created during thermal ablation procedures, such as cardiac ablation procedures. When a cardiac ablation procedure is performed, a central area of coagulative necrosis is created at the treatment site. This necrotic region is surrounded by layers of tissues with ultra-structural and electrophysiological changes. Two particular changes include the denaturation of proteins and the formation of ferric iron containing chemical compounds, such as methemoglobin and metmyoglobin. The formation of and distribution of such chemical compounds can be imaged with the appropriate systems and methods. Accordingly, these chemical compounds can be utilized as biomarkers that indicate the presence and physical characteristics of thermal ablation lesions. Imaging can be performed using magnetic resonance imaging, optical imaging, or photoacoustic imaging, as examples.

System and method for imaging biomarkers indicative of cardiac thermal ablation lesions

In a method for detecting rotational orientation and position tracking of an inductively coupled RF (ICRF) coil using a transmit array system, a conventional body birdcage coil is used, but the quadrature hybrid is eliminated to use the two excitation-channels separately. The transmit array system provides RF excitations such that the body birdcage coil creates linearly polarized and circulating RF pulses instead of a conventional rotational forward polarized excitation. Inductively coupled RF (ICRF) coils can be constructed on catheters for detecting rotational orientation and tracking purposes. The modifications on anatomy and ICRF coil images are different due to the RF excitation scheme such that the ICRF coil can be separated from the anatomy in real-time. After separating the ICRF coil from the anatomy, a color-coded image can be reconstructed, for example.

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Toronto, Canada

Haydar Celik