Unitika Ltd.

Hayato Ishihara

Hiroshi Nakajima

Masaaki Onda

Tatsuo Katayama

Kenji Okada

Ryoichi Turutani

A process for the purification of fructose 1,6-diphosphate which comprises subjecting a fructose 1,6-diphosphate-containing solution to anion exchange column chromatography to separate fructose 1,6-diphosphate therefrom, and subsequently subjecting the resulting FDP fraction to a desalting treatment, so as to provide a highly purified FDP preparation useful as a pharmaceutical drug and the like in a high yield.

Process for purifying fructose 1,6-diphosphate

A process for producing fructose-1,6-diphosphate comprising the steps of: (a) enzymatically converting adenosine 5'-diphosphate to adenosine 5'-triphosphate using an acetate kinase-containing microorganism or an extract of the microorganism and phosphate donor; and (b) enzymatically converting a substrate capable of being converted to glucose or fructose to fructose-1,6-diphosphate using the adenosine 5'-triphosphate resulting from step (a) and the acetate kinase-containing microorganism or the extract of the microorganism.

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Kyoto, Japan

Hayato Ishihara