Ono Pharmaceutical Co., Ltd.

Kyocera Document Solutions Inc.

Tohoku University

Nof Corporation

Hayashi Masaki

Shuichi Ohuchida

Yoshinobu Arai

Yoshitaka Konishi

Hirohisa Wakatsuka

Katsuichi Shimoji

Hiroyuki Ito

Nagashima Teruhiko

Shimizu Tamotsu

Tamaki Kenichi

Takamura Masumi

Kuramashi Koji

Yamagishi Yoshihiro

Morita Takashi

Iwabuchi Yoshiharu

Nakaue Takahisa

Nimura Eiji

Makie Ikuo

Prostaglandin I.sub.2 analogues of the formula: ##STR1## (wherein Y represents trans-vinylene or ethylene, R.sup.1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents hydrogen, methyl or ethyl, R.sup.3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, each represent hydrogen or an alkyl group containing from 1 to 8 carbon atoms, n represents 3, 4, 5 or 6, the wavy line  attached to the carbon atoms in positions 11 and 15 depicted in the formula represents .alpha.- or .beta.-configuration or mixtures thereof, and the double bond between C.sub.6 -C.sub.6 is Z or E) are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI.sub.2.

Prostaglandin I.sub.2 analogues

Growing community of inventors

Takatsuki, Japan

Hayashi Masaki