Mitsui Toatsu Chemicals, Incorporated

Mitsui Pharmaceuticals, Inc.

Mect Corporation

Hayao Abe

Akira Awaya

Yoshitaka Nagai

Hisashi Kobayashi

Yusaku Ishizuka

Masanobu Arita

Tomoya Ogawa

Masayoshi Ito

Shoji Yoshimura

Masaaki Numata

Makoto Tanaka

Shohei Shibayama

Toshikazu Yamanouchi

A pharmaceutical composition containing serum thymic factor (FTS) and a method for using FTS containing compositions for treating a variety of immunodeficiencies and autoimmune diseases including multiple sclerosis, Guillain-Barre syndrome, inflammatory neuropathy, polyneuritis and other immunodemyelinating diseases.

Method and pharmaceutical compositions for treating immunodeficiencies

A medicament for prevention and remedy of diseases caused by the infection of viruses is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration: pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn or an ester and an amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.

Method of treating disease caused by the infection of virus

Medicament for prevention and remedy of diseases of the pancreas and

Method for treating multiple sclerosis

A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

Sialic acid-bonded octapeptide and preparation thereof

Growing community of inventors

Mobara, Japan

Hayao Abe