Sandoz Gmbh

Activbiotics, Inc.

Novartis Ag

Hawkins V Maulding

Thomas Kissel

David Bodmer

Jones W Fong

Oskar Nagele

Jane E Pearson

Arthur F Michaelis

Chalom B Sayada

William Bert Geiss

Joseph Raker

Congxiang Zha

Barry Eisenstein

James R Siverly

The invention features a method of delivering a drug to a diseased cell by linking the drug to a rifamycin derivative, compositions that include drug-rifamycin conjugates of the invention, and methods for treating disease using those compositions.

Targeted therapeutics and uses thereof

The invention features sulfhydryl rifamycin compositions, methods of making these compositions, and methods for treating disease using these compositions.

Sulfhydryl rifamycins and uses thereof

The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for treating microbial infections using those compositions.

Antimicrobial agents and uses thereof

The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

Sustained release formulations of water soluble peptides

The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

The invention concerns a new system and method for iontophoretically delivering a polypeptide transdermally into animal tissue.

Iontophoretic delivery of peptides

A non-irritating injectable dosage form of a tissue irritating medicament, comprising the medicament and a pharmaceutically acceptable glyceride vehicle comprising a glycerol ester of a saturated or unsaturated fatty acid having from 6 to 20 carbon atoms or mixtures thereof.

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Mendham, NJ, United States of America

Hawkins V Maulding