Wakamoto Pharmaceutical Co., Ltd.

Hatsunori Toyofuku

Kenji Naito

Jun Matsumoto

Makoto Maeda

Masayoshi Goto

Toshie Takahashi

Akira Naito

Shohei Sawaki

Toshio Kuroda

Mitsuzi Agata

Yoshihiro Tsuriya

Ryoki Takahashi

Mitsuji Agata

Daisuke Morizono

Yoshiaki Saito

Naomi Sasada

Yasuhiro Ohtake

Hitoshi Aoki

Hidehiko Matsukawa

Hiroshi Nagasawa

Masakazu Ebie

A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof:

Biphenyl derivatives and drug composition

The tetrazolylphenyl pivalate of the the following general formula or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom, a lower alkyl group or other substituents; an elastase-inhibitory composition, a composition for preventing and treating emphysema and a composition for preventing and treating endotoxin-induced lung disorders each comprising the foregoing tetrazolylphenyl pivalate derivative or a non-toxic or acid-addition salt thereof.

Tetrazolylphenyl pivalate derivatives and medicinal composition

A 1,2,4-oxadiazole derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl or cycloalkyl group, a lower alkyl group substituted with a halogen atom, a lower alkylamino group or a phenyl group; R.sup.2 represents a hydrogen atom, a lower dialkylamino group, a cyclic alkylamino group, a cyclic amino group having an oxygen or nitrogen atom in the ring, a phenyl group which may be substituted with a halogen atom, a pyridyl group, an imidazolyl group, an alkylimidazolyl group, a benzimidazolyl group or a 2-oxopyrrolidinyl group; and n is 1, 2 or 3. The derivative has excellent monoamine oxidase-inhibitory activity and is effective as a medicine for treating Parkinson's disease.

1,2,4-oxadiazole derivatives having monoamine oxidase B

New 1,3,4-thiadiazole derivatives of the general formula (I): ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## and R.sub.2 represents an amino, lower alkylamino, cyclohexylamino, benzoylamino, mercapto or lower alkylthio group, a process for the production of them and the use of the derivatives as antiulcer agents.

1,3,4-thiadiazole derivatives, process for the production thereof and

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Tokyo, Japan

Hatsunori Toyofuku