Jomaa Pharmaka Gmbh

Bioagency Ag

Other

Universiteit Gent

Hassan Jomaa

Jochen Wiesner

Boran Altincicek

Armin Reichenberg

Oliver Wolf

Ann-Kristin Kollas

Matthias Eberl

Martin Hintz

Serge Van Calenbergh

Timothy Haemers

Vincent Devreux

Mathias Eberl

The invention relates to cells and organisms as well as to methods for producing said cells and organisms, according to which intermediates of the mevalonate-independent pathway for isoprenoid biosynthesis (MEP pathway) are enriched by deleting or inactivating genes. The derivatives can also be enriched by using enzyme inhibitors. The enriched intermediates may be used as substrates in enzyme activity tests. The inventive cells and organisms and the enriched intermediates can further be used in the production of medicaments.

Inactivation of genes of the MEP pathway

The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme inhibitors and in the prophylaxis and treatment of diseases in humans and animals.

Organophosphorous compounds for the activation of gamma/delta T cells

The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, Calkoxy, Calkyl, hydroxy, formyl, trifluoromethoxy, phenyl, heterocyclic, heterocyclic-substituted methyl, aminomethyl, hydroxy methyl, bromomethyl, sulfonyl chloride, acetyl chloride, nitroso and cyano, (b) Ris selected from the group consisting of hydrogen, Calkyl, Ccycloalkyl, aryl, arylalkyl and heterocyclic, and (c) Ris selected from the group consisting of hydroxy and hydroxy-protecting groups, and stereoisomer, solvates and salts thereof. These compounds are useful as anti-infectious and anti-parasitic agents, in particular anti-malaria agents.

Organophosphoric derivatives useful as anti-parasitic agents

Organo-phosphorous compounds for activating gamma/delta T cells

Phosphorous organic compounds and their use

The invention relates to the use of bisphosphonic acids of general formula (I) and derivatives thereof for the therapeutic and prophylactic treatment of infectious processes caused by viruses, bacteria, fungi or parasites in humans and animals, by deactivating the &ggr;&dgr;T cells.

Use of bisphosphonates for the prevention and treatment of infectious processes

Use of compounds with a nitrogen-oxygen heterocycle

The invention relates to organophosphorus compounds of general formula (I) wherein A corresponds to general formula (II), wherein one or more of the carbon atoms, selected from the group C , C , C and their respective substituents can be omitted, and at least one substituent of B to B is a C cycloalkyl (C ) alkyl group, wherein both the C cycloalkyl group and the C alkyl group can have one or more double bonds and one or two carbon atoms of the cycloalkyl group can be substituted by nitrogen, oxygen or sulfur atoms, and wherein both the cycloalkyl group and the alkyl group can be substituted by hydrogen, halogen amine, oxo groups with branched or unbranched C alkyl groups and C alkenyl groups, wherein the C alkyl groups and C alkenyl groups can be substituted by hydrogen, hydroxy, amine, halogen, and oxo groups. The invention further relates to pharmaceutical preparations containing said compounds and to the use thereof for the therapy and prophylaxis of infectious processes in humans and animals, which processes are induced by bacteria, fungi or parasites. The inventive compounds are also used as fungicidal, bactericidal or herbicidal agents in plants.

Organophosphorus compounds and the use thereof

Growing community of inventors

Giessen, Germany

Hassan Jomaa