The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

University of Michigan

The General Hospital Corporation

Hasan B Alam

Peter Rhee

Emily Rhee

Mohammed N Islam

Yongqing Li

Rachel M Russo

Alexander Joseph Rogers

Steven P Broglio

Ioulia Kovelman

Kevin R Ward

Kayvan Najarian

Robert Mitchell Baldwin, Ii

An apparatus is described for measuring hemodynamic or metabolic function of an organ or tissue region of a subject comprising a super-continuum laser operating in the near or short-wave infrared wavelength range and comprising a multi-stage amplifier. A source fiber delivers the super-continuum emission to the organ or tissue region, and a collection fiber receives reflected emission from the region. A detector followed by a processor is used to determine a metabolic state and an oxygenation state of the organ or tissue region. A signal-to-noise ratio of the signal is improved using a dual-arm differential measurement technique.

Organ or tissue hemodynamic and metabolic function measured using super-continuum light sources

Techniques for measuring metabolic tissue state and oxygenation in human or animal models, through optical techniques capable of simultaneous measurement at single region of interest. Simultaneously measuring CCO, oxygenated hemoglobin (HbO), and deoxygenated (HbR) hemoglobin is performed and metabolic activity of the tissue is determined. The methods employ a super-continuum light source and a probe to deliver light to the individual, and reflected light from the individual is analyzed to determine the metabolic function of the individual.

Brain metabolism monitoring through CCO measurements using all-fiber-integrated super-continuum source

A system for maintaining permissive hypotension in a patient includes monitoring of blood perfusion and pressure, combining blood perfusion and pressure data to determine systolic blood pressure, monitoring for detection of systolic blood pressure below a critical threshold value, and providing an alert to perfusion options to maintain permissive hypotension. The system may be adapted to adjust the critical threshold value for systolic blood pressure as treatment progresses.

System for providing continuous systolic blood pressure measurement to maintain permissive hypotension

A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction. The sensitivity of the one-way valves is such that when properly positioned, fluid can flow through the valves and out of the pump without manual compression of the pump and with the aid of gravity power alone.

Portable hand pump for evacuation of fluids

The technology described herein is directed to the treatment of sepsis and/or septic shock by, e.g. administering an agent that can reduce the level of circulating citrullated histones.

Treatment of sepsis and septic shock

Methods for the use of keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) (KC/GRO), apolipoprotein A2 (APOA2), angiotensinogen r (AGT), thyroglobulin (TG), disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), anionic trypsin-1 (PRSS1), complement C4 (C4A), zona pellucida sperm-binding protein 1 (ZP1), neuropilin-2 (NRP2), solute carrier family 13 member 2 (SLC13A2), glucagon-like peptide 2 receptor (GLP2R), lipoma high mobility group protein isoform I-C (HMGIC) fusion partner-like protein 4 (LHFPL4), and claudin-3 (CLDN3) as biomarkers for diagnosis and prognosis, and for monitoring the efficacy of treatment, in hemorrhagic shock (HS).

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Natick, MA, United States of America

Hasan B Alam