Codexis, Inc.

Societe Des Produits Nestle S.a.

Harvinder Chagger Maniar

Oscar Alvizo

Jovana Nazor

Agustina Rodriguez-Granillo

Anna Fryszkowska

Deeptak Verma

Da Duan

Jonathan Vroom

James Nicholas Riggins

Mark A Huffman

Nicholas M Marshall

Margie Tabuga Borra-Garske

Iman Farasat

Christopher Michael Micklitsch

Santhosh Sivaramakrishnan

Joshua N Kolev

Mikayla Jianghongxia Krawczyk

Hao Yang

Dewan Andrews

Nikki Dellas

Ravi David Garcia

Chinping Chng

Nandhitha Subramanian

The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

Engineered galactose oxidase variant enzymes

The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.

Engineered deoxyribose-phosphate aldolases

The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The invention also relates to the use of the compositions comprising the engineered amylase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered amylase polypeptides, as well as methods for making the engineered polynucleotides and amylase polypeptides.

Engineered amylase variants

The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH&#x3c;7) conditions. The invention also relates to the use of the compositions comprising the engineered amylase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered amylase polypeptides, as well as methods for making the engineered polynucleotides and amylase polypeptides.

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Hayward, CA, United States of America

Harvinder Chagger Maniar