Merck + Co., Inc.

Harvey Schwam

Otto W Woltersdorf, Jr

Stuart R Michelson

John M Sondey

John J Baldwin

George D Hartman

Gerald S Ponticello

Samuel L Graham

Wasyl Halczenko

Ruth F Nutt

Kenneth L Shepard

Stephen F Brady

Carl H Hoffman

Martin Hichens

Charles M Habecker

Aryl (or aralkyl)-sulfonylthiophene-2-sulfonamides containing a basic functional group as a substituent are efficacious in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration.

Thiophene sulfonamide antiglaucoma agents

5-Hydroxy-2-benzothiazolesulfonamide is useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are disclosed.

5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of

6-Hydroxy-2-benzothiazolesulfonamide is useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are disclosed.

6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of

Synthetic antigens related to luteinizing hormone-releasing hormone (hereinafter designated LH-RH) having the amino acid composition, pyroglutamyl-histidyl-tryptophanylseryl-tyrosyl-glycyl-leucyl-arginyl-prol yl-glycyl-poly-L-lysine (hereinafter designated pyroglu-his-trp-ser-tyr-glyleu-arg-pro-gly-poly-L-lys) and poly-L-lysyl-glutarylhistidyl-tryptophanyl-seryl-tyrosyl-glycyl-leucyl-arg inylprolyl-glycine amide (hereinafter designated poly-L-lysglutaryl-his-trp-ser-tyr-gly-leu-arg-pro-gly) are prepared by coupling the corresponding decapeptide with poly-L-lysine. The corresponding decapeptides are prepared by controlled stepwise procedures starting with individual amino acid components. These antigens have the property of inducing formation of antibodies to luteinizing hormone-releasing hormone (LH-RH) in animals.

Synthetic antigens of luteinizing hormone releasing hormone

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Lafayette Hill, PA, United States of America

Harvey Schwam