The Upjohn Co.

Pharmacia & Upjohn Company

Other

Harvey I Skulnick

Wendell Wierenga

Paul A Aristoff

Suvit Thaisrivongs

Gordon L Bundy

Herman W Smith

Ruben Alberto Tommasi

Robert J Smith

Robert C Kelly

Joseph Walter Strohbach

Ronald B Gammill

David John Anderson

Paul D Johnson

Steven Ronald Turner

Karen Rene Romines

Roy A Johnson

Joel Morris

Louis L Skaletzky

Eldon George Nidy

Harold E Renis

Linda Louise Maggiora

W Jeffrey Howe

Clark W Smith

James H Hunter

Theresa M Schwartz

George P Luke

James M Tustin

Jackson B Hester, Jr

Richard Charles Thomas

Robert Alan Chrusciel

Dale A Stringfellow

Paul K Tomich

Michael John Bohanon

Robert A Chruscial

Chih-Ping Yang

Lee S Banitt

Qingwei Zhang

This invention provides 7-deoxy-taxol analogs of Formula I: The compounds of Formula I (including II and III) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

Method of preparing a taxol derivative

The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl&lsqb;b&rsqb;pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.

Compounds useful to treat retroviral infections

Substituted tetronic acids useful for treating HIV and other retroviruses

.DELTA..sup.6,7 -taxols antineoplastic use and pharmaceutical

Pyranone compounds useful to treat retroviral infections

4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl�b!pyran-2-ones

This invention provides 7-deoxy-.DELTA..sup.6,7 -taxol and 7-deoxy-.DELTA..sup.6,7 -taxol analogs of Formula I: ##STR1## The compounds of Formula I are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

.DELTA..sup.6,7 -taxols antineoplatic use and pharmaceutical

6-Aryl pyrimidinol compounds, also can be named 6-aryl pyrimidinone or 6-aryl-isocytosine novel compounds, also novel and old compounds useful for treating viral infections and inducing interferon production. Dosage forms and method of treatment are disclosed.

6-aryl pyrimidine compounds and method for treating viral infections and

Disclosed are .DELTA..sup.9(11) -steroids of the formula ##STR1## which have been found to be angiostatic and therefore are useful in the control of embryogenesis, inflammatory conditions, tumor growth as well as other abnormalities.

.DELTA..sup.9(11) -angiostatic steroids

4-substituted-6-aryl-pyrimidine compounds

A process for treating hypertension comprising the systemic administering to a hypertensive subject or a novel compound of the formula: ##STR1## wherein X is alkyl of from 1 to 3 carbon atoms, inclusive, or alkenyl of from 3 to 5 carbon atoms, inclusive.

Novel compounds and process for treating hypertension

This invention relates to the use of 6-aryluracils as antiinflammatory and antiarthritic agents and also to both novel intermediates and novel processes for the preparation of selected 6-aryluracils.

Use of 6-aryluracils as antiinflammatory and antiarthritic agents

Processes for the preparation of 6-aryluracils

Process for the preparation of 1,3-oxazine-4-ones

Growing community of inventors

Kalamazoo, MI, United States of America

Harvey I Skulnick