Takeda Pharmaceutical Company Limited

Haruyuki Nishida

Atsushi Hasuoka

Masahiro Kajino

Yasuyoshi Arikawa

Ikuo Fujimori

Terufumi Takagi

Keizo Hirase

Koji Ono

The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R, Rand Rare each a hydrogen atom, a halogen atom, a Calkyl group optionally substituted by halogen or a Calkoxy group optionally substituted by halogen, Rand Rare each a hydrogen atom, a halogen atom or a Calkyl group optionally substituted by halogen, Ris a hydrogen atom, a halogen atom, a Calkyl group optionally substituted by halogen or a Calkoxy group optionally substituted by halogen, and Ris a hydrogen atom or a Calkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.

Pyrrole compounds

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity, which is represented by the formula (I) wherein Ris an optionally substituted cyclic group, Ris a substituent, Ris an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, Rand Rare each a hydrogen atom, an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, Rand Rare each a hydrogen atom or an alkyl group, and n is an integer of 0-3, or a salt thereof.

Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like. A compound represented by the formula wherein Ris a substituent, Ris (i) a hydrogen atom, (ii) a Calkyl group optionally having a halogen atom or (iii) a cyano group, Ris (i) a hydrogen atom, (ii) a halogen atom, (iii) a cyano group, (iv) a Calkyl group optionally having a halogen atom or a Calkoxy group optionally having a halogen atom, one of Rand Ris a hydrogen atom, and the other is a substituent other than a hydrogen atom, or a salt thereof.

Pyrazole compound

The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms Xand Xare each a carbon atom or a nitrogen atom, a ring-constituting atom Xis a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, Ris an optionally substituted aryl group or an optionally substituted heteroaryl group, Ris an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, Ris an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X, Xand X, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.

Aryl- or heteroaryl-sulfonyl compounds as acid secretion inhibitors

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein Ris a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), Ris an optionally substituted Caryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, Rand Rare each a hydrogen atom, or one of Rand Ris a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and Ris an alkyl group or a salt thereof. 

1-heterocyclylsulfonyl, 3-aminomethyl, 5- (hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein Ris a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), Ris an optionally substituted Caryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, Rand Rare each a hydrogen atom, or one of Rand Ris a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and Ris an alkyl group or a salt thereof.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein Ris a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), Ris an optionally substituted Caryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, Rand Rare each a hydrogen atom, or one of Rand Ris a hydrogen atom and the other is an optionally substituted lower alkyl pup, an acyl group, a halogen atom, a cyano group or a nitro group, and Ris an alkyl group or a salt thereof. 

1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-)aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors

Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like. A compound represented by the formula (I) or a salt thereof: 

5-Membered heterocyclic compound

1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors

The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. The compound has superior acid secretion inhibitory action, an antiulcer activity and the like.

Growing community of inventors

Osaka, Japan

Haruyuki Nishida