Eisai Company, Limited

Haruyoshi Arai

Isao Yamatsu

Takeshi Suzuki

Akiharu Kajiwara

Seiichi Araki

Masaichi Yamamoto

Yoshikazu Suzuki

Hiroshi Yamamoto

Nozomu Koyanagi

Hiroshi Shionoya

Hitoshi Takeuchi

Shizumasa Kijima

Kimio Hamamura

A &bgr;,&ggr;-dihydropolyprenyl alcohol derivative having the formula:

&bgr;,&ggr;-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

Beta, gamma-dihydropolyprenyl alcohol derivatives and pharmaceutical

Various .beta.,.gamma.-dihydropolyprenyl alcohol derivatives having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group are effective at pritigating stress in animals.

.beta., .gamma.-dihydropolyprenyl alcohol derivatives effective at

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and usrful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

.beta.,.gamma.-dihydropolyprenyl alcohol derivatives and pharmaceutical

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a phylactic agent against human and animal infectious diseases. Other disclosed polyprenyl compounds are also useful as such agents.

An immunopotentiator comprising ricin as an active ingredient. Ricin is a glucoprotein having a molecular weight of about 65,000 and can be used in the form of an aqueous solution. It is useful for prevention and treatment of bacterial and viral infections and cancer.

Immunopotentiator containing recin

An immunopotentiator comprising abrin as an active ingredient. Abrin is a glucoprotein having a molecular weight of about 65,000 and can be used in the form of an aqueous solution. It is useful for prevention and treatment of bacterial and viral infections.

Immunopotentiator containing abrin

Novel 5-fluorouracil derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen atom or methyl group, and R.sub.4 represents a straight or branched alkyl or alkenyl group, which has low toxicity and improved antitumor activity, and novel antitumor preparations containing the said 5-fluorouracil derivative.

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Inuyama, Japan

Haruyoshi Arai