Japan Science and Technology Agency

Japan Science and Technology Corporation

Haruro Ishitani

Shu Kobayashi

Yasuhiro Yamashita

An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or s configuration, and the triol is represented by the following formula: wherein, Y is divalent hydrocarbon and Ris a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons.

Asymmetric reaction catalyst and method for preparing optically active compound using the same

An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (wherein, Y is divalent hydrocarbon and Ris a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons).

An intramolecular [3+2] cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide represented by the following formula (I):Zr(OR)&#x2003;&#x2003;(I)(wherein R is a hydrocarbon group which may have a substituent) with a binaphthol derivative represented by the following formula (II): (wherein Yand Yare each identical or different and denote a hydrogen atom or a halogen atom, and at least one of Yand Ydenotes a halogen atom).

Process for asymmetric intramolecular [3+2] cyclo-addition of hydrazones

Optically active fluorinated binaphthol derivative

An aldehyde compound is reacted with an amino compound and hydrogen cyanate in the presence of a chiral zirconium catalyst obtained by mixing a zirconium alkoxide with an optically active binaphthol compound.

Growing community of inventors

Tokyo, Japan

Haruro Ishitani