Nippon Shinyaku Company, Ltd.

Haruo Tanaka

Hiroshi Enomoto

Shingo Matsumura

Yoshiaki Aoyagi

Yoshiaki Yoshikuni

Shoichi Chokai

Masahiko Kitano

Masakuni Ozaki

Takayuki Ozaki

Koji Kitaguchi

Jun Segawa

Hirotsugu Yoshida

Tatsuhiko Kono

Masato Matsuda

Yoshitsugu Nomiyama

Toshihiro Okamura

Compounds of formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen, halogen or alkyl and R.sup.2 is hydrogen or alkyl are useful to reduce serum lipids in animals, including humans.

Benzoic acid derivatives

4-(3-Aryloxy-2-hydroxypropyl)piperazines bearing a carbamyl group in the 1-position are .beta.-adrenergic blockers. A typical example is 1-carbamyl-4-{3-[2-allyl-3-(2-carbethoxyaminoethyl)phenoxy]-2-hydroxypropy l}piperazine.

Carbamylpiperazine compounds

Oxygenated sterylglycoside derivatives of the formula (I) wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is hydrogen or lower alkanoyl, Y is ##STR1## and R.sub.5 is 4-methylpentyl, 3-ethyl-4-methylpentyl or 3-ethyl-4-methyl-1-pentenyl are useful for their hemostatic and capillary stabilizing effects.

Steroid glycoside compounds and methods of use

4-(3-Aryloxy-2-hydroxypropyl)piperazines bearing a carbamyl, N-alkyl or N,N-dialkylcarbamyl group in the 1-position are .beta.-adrenergic blockers. A typical example is 1-carbamyl-4-(3-phenoxy-2-hydroxypropyl)piperazine.

Carbamyl piperazine derivatives

1-Substituted-9H-pyrido[3,4-b]indole derivatives, which are further optionally substituted in the 3- or 4-position, are inhibitors of xanthine-oxidase. A representative embodiment is 1-formyl-4-hydroxy-9H-pyrido[3,4-b]indole which can be prepared through the processing of Picrasma quassioides.

9H-Pyrido[3,4-b]indole derivatives

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Hikone, Japan

Haruo Tanaka