Dainippon Sumitomo Pharma Co., Ltd.

Japan Energy Corporation

Haruo Takaku

Yoshiaki Isobe

Haruhisa Ogita

Masanori Tobe

Ayumu Kurimoto

Tetsuhiro Ogino

Hajime Kawakami

Hitoshi Fujita

Hiroyuki Matsui

Nobuyoshi Chiba

Kohsaku Hirota

Hiroyuki Morita

Hironao Sajiki

Yoshiaki Kiso

Tsutomu Mimoto

Hideyuki Tomizawa

Keisuke Terashima

Satoshi Nojima

Harumi Satoh

Yoichi Ohba

A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; Xrepresents oxygen, sulfur, NR(Rrepresents hydrogen or alkyl), or a single bond; Yrepresents a single bond, alkylene, etc.; Yrepresents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Qand Qrepresents &#x2014;COOR(wherein Rrepresents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

Adenine compound and use thereof

This invention relates to an adenine derivative, a tautomer thereof, or a pharmaceutically acceptable salt thereof represented by general formula (I): wherein X represents NR(wherein Rrepresents a hydrogen atom or Calkyl) or the like; Rrepresents substituted or unsubstituted alkyl or the like; Rrepresents hydroxyl or the like; and Y represents a substituted or unsubstituted aromatic hetero ring or the like. Also, the present invention relates to pharmaceuticals such as an interferon inducer, antiviral agent, anticancer agent, type 2 helper T cell selective immune response inhibitor, antiallergic agent, and immune response modulator comprising the above derivative as an active ingredient.

Adenine derivatives

Type 2 helper T cell-selective immune response suppressors

A novel tripeptide compound represented by the following general formula (I) exhibiting superior HIV protease inhibition activity, and an anti-AIDS medicine comprising this compound as an effective component and a pharmaceutically acceptable salt thereof.

Tripeptide compounds and anti-AIDS medicine

Purine derivative

The present invention relates to a pyrazole derivative represented by formula (I) or (II) ##STR1## wherein R.sup.1 is hydrogen C2-C6 alkyl benzyl or phenyl; each of R.sup.2 and R.sup.3 is hydrogen, C1-C6 alkyl or benzyl; each of R.sup.4 and R.sup.5 is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl, benzyl or phenyl;

Pyrazole derivatives and their pharmaceutical use

Growing community of inventors

Osaka, Japan

Haruo Takaku