Mect Corporation

Fuji Photo Film Company, Limited

Meiji Seika Kaisha, Ltd.

Kanto Ishi Pharmaceutical Co., Ltd.

Haruo Ogura

Masayoshi Ito

Yoshiyasu Shitori

Kimio Furuhata

Yoshitaka Nagai

Toshiaki Osawa

Satoshi Toyoshima

Shingo Sato

Hidefumi Sera

Kunio Ishigaki

Atsuaki Arai

Shoji Yoshimura

Ichiro Ishikawa

Masasi Ogawa

Motoo Hozumi

Tsuneo Itoh

Katuji Kitatani

Norio Kawahara

Yoshio Honma

The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.

Sialosyl cholesterol and neuropathy remedy comprising the same

Sialosyl cholesterol, process for producing the same, and neuropathy

As new compounds are now provided 7,7,8,8,-tetramethyl-cis-diaza-bicyclo{4.2.0}octane-3,5,-dione derivatives which have an activity to induce the differentiation of tumor cells and are useful as antitumor agent, and which also have an antiviral activity against various viruses and are useful as antiviral agent. These new derivatives may be produced by a photo-addition reaction of a uracil compound with 2,3-dimethyl-2-butene.

New tetramethyl-cis-diaza-bicyclo{4.2.0}octane-3,5-dione derivatives

A new process for preparing halides of N-acetylneuraminic acids useful as an intermediate in preparing new N-acetylneuraminic acid derivatives having an excellent immunological activity is provided, which process comprises simultaneously acetylating and halogenating an esterified N-acetylneuraminic acid with the aid of an acetyl halide, and according to the process, the halides may be obtained in high yield of about 90%.

Process for preparing N-acetylneuraminic acid derivatives

This invention provides a novel compound having the following formula: ##STR1## This compound is a useful intermediate for the preparation of N-glycolylneuraminic acid: ##STR2##

N-glycolylneuraminic acid derivative

A novel N-acetylneuraminic acid derivative, represented by the general formula: ##STR1## wherein the R.sup.1 groups are, independently, hydrogen or acetyl; R.sup.2 is a nucleoside residue; and R.sup.3 is carboxyl or methoxycarbonyl. The N-acetylneuraminic acid derivative is useful in inhibiting metastasis of cancer cells. Also provided is a process for the preparation of the derivatives.

Sialic acid derivative and process for preparing the same

Nucleoside or glucose derivatives of N-acetylneuraminic acids are provided, which have immunological activity, are clinically useful, as an immuno suppressive, in particular to treat autoimmune disease such as collagenosis disease without causing any serious side-effects and may be prepared by subjecting a halide of N-acetylneuraminate derivative together with a nucleoside or a glucose to Koenigs-Knorr reaction.

N-Acetylneuraminic acid derivatives and the preparation thereof

A method of hardening gelatin is described comprising treating gelatin with a compound of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 can each represent a monovalent group including a carbon atom or a nitrogen atom forming a bond together with the nitrogen atom N forming an acid ester in the formula (I); or R.sup.1 and R.sup.2 together can form a heterocyclic ring together with said nitrogen atom N, and

Method of hardening gelatin

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Matsudo, Japan

Haruo Ogura