Ajinomoto Co., Ltd.

Other

Kazuo Sugamura

Harumi Nakazawa

Junji Hamuro

Toshiro Shimamura

Toshikazu Takeshita

Yuka Kanayama

A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.

.gamma.-chain humaninterleukin-2 receptor polypeptide and method of

Peptides which inhibit the binding of human IL-6 to human IL-6 receptor are useful as a treatment for diseases induced or aggravated by IL-6. DNA fragments, vectors, transformants, and methods useful for preparing such peptides are described.

Immunosuppressant

Monoclonal antibodies which bind the gamma chain of human interleukin-2

Growing community of inventors

Kawasaki, Japan

Harumi Nakazawa