Ajinomoto Co., Ltd.

Ea Pharma Co., Ltd.

Harumi Arisaka

Hiroshi Yamamoto

Takashi Yamamoto

Koichi Ishii

Ryota Yoshimoto

Shingo Makino

Masataka Shoji

Naoto Koyama

Kenji Shinkai

Hirokazu Ueno

Tomoko Miyazawa

Toshiyuki Takanohashi

Tetsuya Seki

Provided is a sulfonamide derivative represented by the following general formula (1) and having an &#x3b1;4 integrin inhibitory effect with high selectivity with a low effect on &#x3b1;4&#x3b2;1 and a high effect on &#x3b1;4&#x3b2;7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R, and a to h are as described in the description).

Sulfonamide derivative and pharmaceutical use thereof

Plant seed extract compositions obtained by washing a defatted plant seed with water, and extracting the resulting washed seed product with an organic solvent and safflower seed extract compositions wherein the weight ratio of the total content of (a) p-coumaroylserotonin, feruloylserotonin, p-coumaroylserotonin glycoside, and feruloylserotonin glycoside to (b) 2-hydroxyarctiin is 1:0.01 to 0.2, are effective for reducing the risk of developing atherosclerosis and diseases caused by atherosclerosis and also exhibit a reduced tendency to cause diarrhea.

Plant seed extract composition and process for producing the same

The present invention also relates to a method of using these novel materials, and other materials, to treat or prevent a disease caused by serotonin or a method of treating or preventing platelet aggregation. The compounds used are piperidine derivatives having the formula (I): ##STR1## wherein the various substituents are defined below.

Piperidine derivatives and anti-platelet agents containing the same

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Kawasaki, Japan

Harumi Arisaka