Daiichi Pharmaceutical Co., Ltd.

Trine Pharmaceuticals, Inc.

Haruko Kawato

Makoto Takemura

William John Watkins

Aesop Cho

Kenichi Kimura

Kiyoshi Nakayama

Youichi Kimura

Hitoshi Ohki

Katsuhiro Kawakami

Monica H Palme

Masami Ohtsuka

Jason Zhang

Norikazu Matsuhashi

A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I):wherein, Rand Rrepresent hydrogen atom, a halogen atom, hydroxyl group or the like, Wrepresents &#x2014;CH&#x2550;CH&#x2014;, &#x2014;CHO&#x2014;, &#x2014;CHCH&#x2014; or the like; Rrepresents hydrogen atom, a halogen atom, hydroxyl group or an amino group; Rrepresents hydrogen atom, a group of &#x2014;OZR(Zrepresents an alkylene group, a fluorine-substituted alkylene group or a single bond, and Rrepresents a cyclic alkyl group, an aryl group or the like); Wrepresents a single bond or &#x2014;C(R)&#x2550;C(R)&#x2014; (Rand Rrepresent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but Wand Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

Drug efflux pump inhibitor

Pyridonecarboxylic acid derivatives substituted by a bicyclic amino

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Tokyo, Japan

Haruko Kawato