Chugai Seiyaku Kabushiki Kaisha

Haruki Ogawa

Hiroshi Okazaki

Takao Noto

Yusuke Harada

Isao Matsunaga

Minoru Shindo

Nobuhiro Oi

Teizo Shinozaki

Takao Kimura

Hisao Endo

Toshiyuki Nebashi

Kanji Moro

Bunya Aoki

Yutaka Sugawara

Mitsuaki Handa

Akihiro Yamamoto

Kunio Ando

Takashi Matsuno

Tsutomu Kawaguchi

Yasuhisa Takeda

Hiroshi Sasaki

Hiroko Usami

Masahiko Matsumoto

Toshio Kuroki

Yoshiharu Nawata

Hiroki Mitsui

Hideo Oishi

Kana Kojima

Hisako Masuda

Mihoko Ohtaka

.alpha.-Substituted ureido-benzylpenicillanic acids of the formula ##STR1## (wherein R.sup.1, X and Y are as defined in the description) and pharmaceutically acceptable salts thereof, and a bactericidal composition comprising the above penicillanic acid or the salt and a pharmaceutically acceptable carrier are disclosed. The acids and salts thereof have high antibacterial activities against Gram-positive and Gram-negative bacteria, particularly those of the genus Pseudomonas.

.alpha.-Substituted ureido-benzylpenicillanic acids

An anti-tumor preparation containing cells of Streptococcus equisimilis and a process for preparing the preparation which comprises subjecting the cells to heat treatment in a salt solution with or without penicillin treatment.

Anti-tumor preparation against certain tumors and process for preparing

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1 R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Cephalosporin derivatives

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

An anti-tumor substance which is not only heatstable but also has low inflaming and pain-inducing properties and low pyrogenic activity is disclosed. The substance is prepared by disrupting cells of bacteria belonging to hemolytic streptococci, extracting from the disrupted material a water-insoluble substance and treating the substance with one or more proteases and, optionally, with one or more nucleases.

Anti-tumor substance and process for preparing the same

Penicillanic acid derivatives which have an excellent antibacterial action particularly against bacteria belonging to family Pseudomonas aeruginosa and are represented by the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 and n are as defined above, and salts thereof; and a process for preparing the same are disclosed.

Penicillanic acid derivatives

A novel antibiotic No. 2-200 represented by the formula ##STR1## which has a broad antimicrobial spectrum and a process for producing the same by cultivating an antibiotic No. 2-200 producing microorganism of the genus Nocardia, and recovering by isolation the antibiotic No. 2-200 accumulated in the culture.

Antibiotic No. 2-200 and process for producing thereof

Growing community of inventors

Chofu, Japan

Haruki Ogawa