The University Of Electro-Communications

Campus Create Co., Ltd.

Haruki Niwa

Shojiro Maki

Tsuyoshi Saito

Shigeru Nishiyama

An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.

Luminescent substrate for luciferase

The present invention relates to a compound having a structure analogous to firefly luciferin. In particular, the invention relates to a heterocycle compound which produces a luminescence at a light wavelength different from that of firefly luciferin in nature. The present invention provides a heterocycle compound of following general formula I. In the above general formula, R, Rand Rcan be each independently H or C-alkyl. In the above general formula, X and Y can be each independently C, N, S or O. In the above general formula, the olefin chain part expressed as 'n' can be changed to desired length. 

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Tokyo, Japan

Haruki Niwa