Suntory Limited

Suntory Holdings Limited

Mitsubishi Chemical Industries Limited

Daiichi Suntory Pharma Co., Ltd.

Shionogi Company Limited

Mitsubishi Chemical Corporation

Asubio Pharma Co. Ltd.

Daiichi Asubio Pharma Co., Ltd.

Harukazu Fukami

Ryoji Kikumoto

Masaki Hashimoto

Masahiro Nakao

Kunihiro Ninomiya

Akira Mizuno

Norio Inomata

Makoto Shibata

Naoki Higuchi

Tomoe Kamei

Shinjiro Niwata

Misa Ochiai

Mitsuru Maeda

Akihiro Tobe

Masayuki Saitoh

Mamoru Sugano

Naoko Kawaguchi

Toshio Takahashi

Akiko Ito

Kengo Akimoto

Hiroshi Kawashima

Takaharu Tanaka

Hiroto Hara

Kenichiro Nakao

Mitsuo Egawa

Akio Noguchi

Fumio Fujita

Issei Nitta

Motoo Sumida

Kinya Ide

Seiichi Imajo

Shinya Inoue

Naohiro Watanabe

Hiroaki Kasai

Ryuichi Sago

Saki Kakutani

Norio Ohtsuka

Masaki Kanamori

Toshinao Goda

Yoshiko Ono

Yoshinobu Kiso

Harumoto Kawaguchi

Hideki Okunishi

Eiichi Kakizoe

Hidenori Urata

Keitaro Ikai

Jun Imose

Koshi Namikawa

Yoshiaki Fukuda

Kiso Yoshinobu

Shibata Hiroshi

Saitoh Masayuki

Yoshiaki Tomimori

Kyoji Kikumoto

Maki Asami

The present invention provides a method for preparing a glycoside of a flavonoid compound, which comprises the step of treating flavonoid and a glycosyl donor with an enzymatic agent having glycosylation activity and being derived from the genus(preferablyor). Such a flavonoid compound includes a catechin compound or a methylated derivative thereof, and the glycosyl donor includes a carbohydrate containing a maltotriose residue (preferably maltotriose, maltotetraose, maltopentaose, maltohexaose, maltoheptaose, dextrin, &#x3b3;-cyclodextrin or soluble starch). Glycosides obtained by the present invention have higher water solubility, improved taste, and increased stability. The present invention also provides novel glycosides of catechin compounds, which are obtained by the method of the present invention.

Method for glycosylation of flavonoid compounds

The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus, more preferably), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant ofstrain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.

Polypeptide having glycosylation activity on a flavonoid

Polynucleotide encoding a polypeptide having glycosylation activity on a flavonoid

A lipid-improving agent containing a triglyceride(s) where a poly-unsaturated fatty acid is bonded to 2-position of a triglyceride(s).

Lipid-improving agent and composition containing lipid-improving agent

The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genusand has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further providessp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.

Lipase

The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(&#x3b1;-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from NingxiaL. and/orMill. The compositions comprising 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using &#x3b2;-D-glucosyltransferase. Pure 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding &#x3b1;-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

2-O- (&#x3b2;-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it

The invention provides a process for powdering highly unsaturated fatty acid esters of ascorbic acid which are pasty and problematic in physical properties by a simple and easy means; highly unsaturated fatty acid esters of ascorbic acid which are improved in stability by powdering; and compositions containing the powdered highly unsaturated fatty acid esters of ascorbic acid. Specifically, a process for powdering a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I): RCO-A [wherein RCO&#x2014; is acyl derived from a highly unsaturated fatty acid; and A is an ascorbic acid residue bonded through an &#x2014;O&#x2014; linkage resulting from an hydroxyl group of ascorbic acid], characterized by mixing a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I) with an aqueous solution of a water-soluble filler to form an emulsion and dehydrating and drying the emulsion by a spray drying method.

Process for producing powdered compositions containing highly unsaturated fatty acid esters of ascorbic acid and powdered compositions containing the esters

The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O- (&#x3b2;-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from NingxiaL. and/orMill. The compositions comprising 2-O-(&#x3b2;D-glucopyranosyl) ascorbic acid may be enzymatically synthesized using &#x3b2;-D-glucosyltransferase. Pure 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding &#x3b1;-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

2-O-(&#x3b2;-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it

A composition for external use, comprising 2-O-(&#x3b2;-D-glucopyranosyl)ascorbic acid represented by the formula (I): or a salt or ester thereof which is safe to the human body, and a koji mold or a processed koji. The composition for external use is excellent in skin permeability, containing an ascorbic acid derivative which is excellent in stability, utilized persistently in the living body, and strong in antioxidant activity, and has little skin irritation.

Composition for external use

Medicaments for the treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, having quinazolidone derivatives of formula I or II that are herein defined, are disclosed.

Method of treating dermatitis comprising administering a chymase inhibitor

2-O-(&#x3b2;-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it

An object of the present invention is to provide aextract containing readily water soluble rottlerin. A further object of the present invention is to improve convenience at production steps in a method for producing such an extract, by avoiding the staining of filters and/or pipes during extraction and filtration to reduce washing costs, or by facilitating the introduction of freeze drying and so on. When a dye extract is extracted with water and alcohol from aplant body, the addition of a base component drastically improves the water solubility of theextract. This improves extraction rates of rottlerin, facilitates washing in the production and the pulverization of the extract, and also improves the water solubility of the obtained extract.

[object Object]

A quianazoline derivative having the formula (1): or a pharmaceutically acceptable salt thereof, which has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase and useful as a medicament, and a pharmaceutical composition containing the same as an essential ingredient.

Quinazoline derivatives and pharmaceutical applications thereof

Growing community of inventors

Kyoto, Japan

Harukazu Fukami