Tohoku University

Fuso Pharmaceutical Industries, Ltd.

Gunma University

Junsei Educational Institution

Haruhisa Kikuchi

Yoshiteru Oshima

Osamu Yamada

Jing Zhang

Shinya Kida

Toshio Hattori

Yuzuru Kubohara

Yoshihisa Matsushita

Shinya Murase

Hiroaki Shimokawa

Kimio Satoh

Ryo Kurosawa

Takayuki Doi

Jyunken Aoki

Kuniyuki Kano

The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.

Compound having PD-L1 expression-suppressing action

The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including a compound represented by the following formula (I) or a salt thereof: where: &#x2014;A&#x2014; represents &#x2014;NH&#x2014;, &#x2014;S&#x2014;, or &#x2014;O&#x2014;; Rand Rare identical to or different from each other, and each represent a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom, a halogen atom, or an alkyl group; Rrepresents a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom or an alkyl group; Rand Rare identical to or different each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and Rand Rmay form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which Ris bonded and a carbon atom to which Ris bonded.

Prophylactic or therapeutic agent for pulmonary hypertension comprising unsaturated 5-membered heterocycle-containing compound

The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R, R, R, R, R, R, R, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.

Amide derivative

The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R, R, R, R, R-R, and n are as defined in the present specification.

Indole alkaloid compound having immune checkpoint inhibitory action

Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.

Osteopontin production inhibitor containing dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient

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Sendai, Japan

Haruhisa Kikuchi