National Institute of Advanced Industrial Science and Technology

Shimadzu Corporation

Rion Company Ltd.

Kioxia Corporation

Haruhisa Kato

Yusuke Matsuura

Ayako Nakamura

Kengo Aoki

Kaoru Kondo

Takuya Tabuchi

Hiroki Honda

Hidekazu Hayashi

Masaru Yoshida

Kazuna Bando

Harumi Ohyama

Hiroshi Tomita

Naoko Oouchi

Yoko Matsuzawa

A centrifugal separation type FFF device where a rotor can be rotated at a high speed safely so that particles of a smaller size in a sample liquid can be classified. A field flow fractionation device is provided with: a channel that is attached to the inner circumferential surface of the peripheral portion of a rotor and where a classification flow path is created; flow paths for feeding a sample liquid into and out from the classification flow path; and a rotational drive mechanism for rotating the rotational axis, wherein a channel installation portion is formed on one side of the peripheral portion, and a mass balancer portion for adjusting the mass distribution of the rotor is formed on the other side with the rotor base in between.

Field flow fractionation device including mass balancer portion

For an easy calibration using calibration particles, provided is a measuring device to capture images of target objects. An image analyzer acquires multiple images obtained at a predetermined time interval, (a) specifies the mean-square displacement of a bright point of a calibration particle based on the displacement of the bright point of the calibration particle in the multiple images in a calibration mode, and (b) specifies the mean-square displacement of a bright point of the target particle based on the displacement of the bright point of the target particle in the multiple images in a measurement mode. A particle size analyzer (c) derives the particle size of the target particle from the mean-square displacement of the bright point of the target particle based on the mean-square displacement of the bright point of the calibration particle and the particle size of the calibration particle in an analysis mode.

Particle measuring device, calibration method, and measuring device

The purpose of the present invention is to provide a particulate observation device using light scattering, which includes a means for determining the three-dimensional position of a particle, and can measure an accurate particle size or impart various properties of same. The present invention is characterized by including a position determination means which captures, with an optical microscope, an image of light scattered from particles in a dispersion medium to which laser light is emitted, and determines a three-dimensional position of each particle from the obtained two dimensional image, wherein the position determination obtains two-dimensional coordinates along the two-dimensional image from luminescent point positions of the particles, and determines the depth position along a coordinate axis vertical to the two-dimensional image from the diameters of diffraction fringes of the luminescent points.

Particulate observation device and particulate observation method

Provided is a centrifugal field-flow fractionation device in which a liquid sample is less likely to leak from a channel and attachment and detachment work of a channel member is facilitated. By integrally forming an outer peripheral surfaceand an inner peripheral surfaceof a channel member, the channel memberis configured as one hollow member having a channelformed inside. Thus, pressure resistance performance of the channel memberis improved, formation of a gap in the channelcan be prevented, and deterioration in sealing performance due to secular change is not generated. Accordingly, a liquid sample is less likely to leak from the channel. Further, since the channel membercan be handled as one member, attachment and detachment work of the channel memberis facilitated.

Centrifugal field-flow fractionation device

A measuring method enabling simple and accurate measurement of a flow velocity distribution in a flow field inside a flow passage of an optical cell and a particle size-measuring method using the measuring method are provided. Providing a tracer particle of a smaller size than wavelength &#x3bb; of laser light into the flow passage and capturing a bright spot attributed to light scattering from tracer particles by camera, and obtaining the flow velocity distribution by the analysis unit by obtaining an amount of movement of each tracer particle from movement of the bright spot and correcting a Brownian motion component from a correlation between an average value of variations of the amount of movement and Brownian motion are performed.

Flow velocity distribution measuring method and particle size measuring method

A centrifugal field-flow fractionation device capable of improving analysis performance and shortening analysis time is provided. A first channelcommunicating with a channel member is formed on a rotational shaftthat rotates together with a rotor. A second channelcommunicating with the first channelis formed on a fixing portionfixed in a state of facing the rotational shaftalong a rotational axis L. A mechanical sealhaving a pair of seal ringsandthat come into contact with each other and a biasing memberis provided to attach one seal ringto the rotational shaftand the other seal ringto the fixing portion. The biasing memberbiases the pair of seal ringsandin a direction in which the pair of seal rings come in contact with each other. Since the rotational shaftcan be rotated at a high speed and the liquid sample can be fed at a high pressure, the analysis performance can be improved and the analysis time can be shortened.

Mechanical seal for centrifugal field-flow fractionation device

Provided is a particle measuring device and a particle measuring method for measuring a particle size with favorable accuracy. A flow cell () includes a flow passage () of sample fluid. An irradiation optical system () irradiates, with light from a light source (), the sample fluid in the flow passage (). An imaging unit () captures, from an extension direction of the flow passage (), an image of scattered light from the particle in a detection region in the flow passage (), the light passing through the detection region. A particle size specifying unit specifies a movement amount of the particle in a two-dimensional direction by Brownian motion based on multiple still images of a particle image captured at a predetermined frame rate by the imaging unit (), thereby specifying the particle size of the particle from the movement amount in the two-dimensional direction.

Particle measuring device and particle measuring method

To provide a particle size measuring device that enables simple in-line measurement of the particle size even in a case of nano-sized particles during dispersion. Provided is a particle size measuring device which measures the particle size of particles that perform Brownian motion in a dispersion medium. The particle size measuring device includes a transparent column which accommodates a dispersion medium therein; a laser light irradiating unit which irradiates the dispersion medium in the column with laser light; an imaging unit which includes a camera that images the dispersion medium in the column; an image analyzing unit which acquires a displacement of corresponding particles from at least a plurality of images captured at a predetermined time interval &#x394;t; and a calculating unit which calculates the particle size based on the fact that a root mean square value of the displacement is proportional to kT/3&#x3c0;&#x3b7;d where krepresents a Boltzmann constant, T represents an absolute temperature, &#x3b7; represents a viscosity coefficient of the dispersion medium, and d represents the particle size.

Particle size measuring method and device

A photoresponsive ionic organic compound of formula (I); a method of producing the same; a photoresponsive carbon nanotube (CNT) dispersant; a CNT dispersion containing the dispersant; and a method of separating a CNT from the dispersion: wherein R, R, and Reach represent a hydrogen atom or an alkyl group; A represents &#x2014;CH&#x2014; or a nitrogen atom; X represents an anion; and n is a number to give a charge of &#x2212;2 to nX.

Photoresponsive ionic organic compound, method of producing the same, and photoresponsive carbon nanotube dispersant comprising said ionic organic compound

Growing community of inventors

Tsukuba, Japan

Haruhisa Kato