Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Haruhiko Manabe

Fumio Suzuki

Kenji Ohmori

Etsuo Ohshima

Takeshi Kuroda

Yoshisuke Nakasato

Hidee Ishii

Kyoichiro Iida

Koji Yanagawa

Takashi Kawakita

Tohru Matsuzaki

Katsuichi Shuto

Michio Ichimura

Shigeto Kitamura

Soichiro Sato

Rie Koike

Akira Karasawa

Akio Ishii

Junichi Shimada

Hiroyuki Obase

Tetsuji Ohno

Ichiro Miki

Shizuo Shiozaki

Takeshi Kuboyama

Hitoshi Arai

Etsuo Oshima

Toshiaki Kumazawa

Tadafumi Tamura

Masatoshi Yamato

Yoshiaki Masuda

Yoshikazu Miwa

Nobumasa Otsubo

Mayumi Saki

Kuniko Hashigaki

Naoko Hiura

Jun Saito

Hidenori Takada

Yoshisuke Nakazato

Kazuihiro Kubo

Shizuo Otaki

The present invention provides a preventive and/or therapeutic agent for neutrophilic inflammatory diseases which comprises, as an active ingredient, a bicyclic heterocyclic compound represented by formula (I): [wherein Rrepresents a hydrogen atom, substituted or unsubstituted alkyl, or the like, A-A-A-Arepresents N&#x2550;CR&#x2014;CR&#x2550;CR(wherein R, R, and Rare the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like), Q represents substituted or unsubstituted phenylene, and the like, and T represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aroyl, and the like].

Preventive and/or therapeutic agent for neutrophilic inflammatory diseases

Derivatives of benzofuran or benzodioxazole compounds

Derivatives of benzofuran or benzodioxole

Benzofuran derivatives

Oxygen-containing heterocyclic compounds

Imidazonaphthyridine derivatives

Thienoimidazoppyridone derivatives

There are disclosed s-triazolo[3,4-i]purine derivatives represented by formula: ##STR1## wherein Y-Z represents ##STR2## R.sub.4 represents hydrogen, alkyl, substituted or unsubstituted aromatic heterocyclic group or substituted or unsubstituted aryl; and X.sup.2 represents oxygen, sulfur or NH; each of R.sup.1 and R.sup.2 independently represents hydrogen, alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; R.sup.3 represents alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; X.sup.1 represents oxygen or sulfur; and  represents a single bond or a double bond or pharmaceutically acceptable salts thereof.

s-Triazolo(3,4-I)purine derivatives

Disclosed is a novel arylalkylamine derivative represented by the formula (I) ##STR1## wherein X represents --O--, --CH.sub.2 -- or --NR.sup.3 -- in which R.sup.3 represents hydrogen or lower alkyl;

Arylalkylamine derivatives

Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.

Dibenz[b,e]oxepin derivative and pharmaceutical compositions thereof

Novel imidazoquinolone derivative represented by formula (I); ##STR1## wherein R.sup.1 represents lower alkyl or --(CH.sub.2).sub.m CO--R.sup.3 where R.sup.3 represents hydrogen, lower alkyl, hydroxy or lower alkoxy; and m is an integer of 1 to 3; R.sup.2 represents lower alkyl; or a pharmaceutically acceptable salt thereof.

Imidazoquinolone derivatives

Novel imidazoquinolone derivative represented by the formula (I); ##STR1## wherein R.sup.1 represents hydrogen, alkyl, cycloalkyl, alkenyl aralkyl, aralkenyl or substituted or unsubstituted aryl; X represents nitrogen or ##STR2## where R.sup.2 is hydrogen, hydroxyl, alkyl, cycloalkyl, alkenyl, aralkyl, aralkenyl, substituted or unsubstituted aryl, thiol, halogen, substituted or unsubstituted aromatic heterocyclic group, or --(CH.sub.2).sub.m CO.sub.2 R.sup.6 where R.sup.6 is hydrogen or lower alkyl and m is an integer of 0 to 3; Y represents oxygen or sulfur; R.sup.3 represents alkyl, cycloalkyl, alkoxyalkly, alkenyl, aralkyl, aralkenyl, --(CH.sub.2).sub.n -- Het where Het is substituted or unsubstituted aromatic heterocyclic group and n is an integer of 1 to 3 or --(CH.sub.2).sub.n CO.sub.2 R.sup.6a where n has the same meaning as defined above and R.sup.6a has the same meaning as defined as to R.sup.6 ; each of R.sup.4 and R.sup.5 independently represents hydrogen, lower alkyl, trifluoromethyl, cycloalkyl, halogen, hydroxyl, lower alkoxyl, lower alkylthio, nitro, amino, lower alkylamino, lower alkanoylamino, aroylamino, lower alkanoyl or aroyl; and a pharmaceutically acceptable salt thereof. The Compound (I) and a pharmaceutically acceptable salt thereof show bronchodilatory and antiallergic activities, and are useful for treating respiratory disorders such as bronchial asthma.

Growing community of inventors

Shizuoka, Japan

Haruhiko Manabe