Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Takeda Chemical Ind., Ltd.

Takeda Chemical Corporation

Haruhiko Makino

Atsuo Baba

Takashi Sohda

Tsuneo Yasuma

Isao Aoki

Toshiaki Nagata

Akira Mori

Taihei Yamane

The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I): wherein G is a halogen atom, hydroxyl group, an optionally substituted amino group, etc.; alk is an optionally substituted lower alkylene group; X is O, S, &#x2014;(CH)&#x2014;, etc.; R is an optionally substituted amino group, etc.; ring B is an optionally substituted Y-containing 5- to 8-membered ring whose ring constituent atoms contain no nitrogen atom; Y is O, S, a group of (wherein Ra, Rb and Rc are the same or different and, each is H, a halogen atom, an optionally substituted hydrocarbon group, etc.), etc.; and ring A may be substituted.

Thienopyridine derivatives, their production and use

Benzothiepine derivatives, their production and use

Thienopyridine derivatives and their use

Benzothiepin derivatives, process for the preparation of the same and uses thereof

Thienodipyridine derivatives, production and use thereof

There is disclosed an anti-inflammatory agent comprising a compound of the formula (I): ##STR1## The quinoline compounds included in the compound (I) are novel and there is also disclosed processes for producing them.

Pharmaceutical composition containing quinoline and quinazoline

A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C-G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted for; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

Quinoline or quinazoline derivatives, their production and use

A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C--G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted for; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

Thienopyridine or thienopyrimidine derivatives and their use

Pharmaceutical composition containing quinoline or quinazoline

The present invention provides a novel quinoline derivative useful as an anti-inflammatory agent, particularly an agent for treating arthritis, or a salt thereof. The present invention also provides a composition, particularly an anti-inflammatory composition for pharmaceutical use, comprising the novel quinoline compound of formula (I): ##STR1## wherein G is an acyl group, optionally protected hydroxyalkyl group, amidated carboxyl group or halogen atom; X is an oxygen atom, optionally oxidized sulfur atom or --(CH.sub.2).sub.q -- in which q is an integer of 0 to 5; R is an optionally substituted amino group or optionally substituted heterocyclic group; each of the ring A and ring B may optionally be substituted; and k is 0 or 1.

Quinoline derivatives and pharmaceutical composition containing them

A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C--G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted or unsubstituted; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

Growing community of inventors

Hyogo, Japan

Haruhiko Makino