Nisshin Flour Milling Co., Ltd.

Nisshin Chemicals Co., Ltd.

Haruhiko Kikuchi

Hiroaki Satoh

Koichiro Hagihara

Setsuko Mino

Masashi Suzuki

Takeo Arai

Toru Hayakawa

Ruta Fukutomi

Makoto Yanai

Masahiro Ueno

Yumiko Noguchi

Kohei Inomata

Toshio Suguro

Ryuta Fukutomi

Sugure Taniguchi

Nobuhiro Yahata

Haruko Eguchi

Kenji Mori

Kazuhiko Yamada

Kiochiro Hagihara

An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.

Indazole compound containing a monocyclic amine structure

Indazole derivatives having monocyclic amine

Diaminomethylidene derivatives

Pyrimidine derivatives

Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.

5-HT.sub.4 receptor agonists

Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;

Diazabicyclo derivatives

Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;

Azabicyclo derivatives

Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Piperidine derivatives

Azabicyclo derivatives and their use as antiemetics

Disclosed are compounds of formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, benzyl or an indolyl carbonyl group, R.sub.2 is a saturated or unsaturated 5- or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C.sub.1 -C.sub.6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain --(CH.sub.2).sub.n -- are optionally substituted by a C.sub.1 -C.sub.6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Indole derivatives

A process of preparing l-biopterin is disclosed which comprises the steps of:

Process for the preparation of pterin derivatives

An improved process for preparing 4-(4-biphenylyl)-4-oxo-butanoic acid which is useful as anti-inflammatory and analgesic agents. The process comprises reacting biphenyl with succinic anhydride in chlorobenzene in the presence of anhydrous aluminum chloride. No 4-(4-chlorophenyl)-4-oxo-butanoic acid is produced as by-product.

Process for preparing 4-(4-biphenylyl)-4-oxo-butanoic acid

L-carnitine and salts thereof are resolved from DL-carnitine by the use as a resolving agent of dibenzoyl-L(+)tartaric acid. L-carnitine is known as vitamin B.sub.T and is useful as a medicine.

Growing community of inventors

Saitama, Japan

Haruhiko Kikuchi