Oki Electric Industry Co., Ltd.

Tokyo Metropolitan Institute of Medical Science

Haruhiko Akiyama

Masato Hasegawa

Takashi Nonaka

Makiko Yamashita

Tetsuaki Arai

Manabu Kawabe

Atsushi Fukasawa

Takuro Sato

Tetsuo Onodera

Eiichi Nakanishi

Kanji Arai

Masami Masuda

Katsumi Tokuyama

Fuyuki Kametani

Takuji Ishikawa

The purpose of the present invention is to develop a method for amplifying in vitro to a large amount of a homogenous insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate including TDP-43 protein and fragments thereof according to the present invention includes the steps of: (1) introducing an insoluble fraction originated from the brain of a neurodegenerative disease patient into a cell culture in which the intact TDP-43 protein can be expressed in a constitutive manner; (2) culturing the cultured cell into which the insoluble fraction has been introduced; and (3) separating an insoluble fraction from the cultured cell. Optionally, the method may additionally include a step of amplifying the insoluble aggregate of the neurodegenerative-disease-related protein in the cultured cell.

Method for producing insoluble aggregate of neurodegenerative-disease-related protein

Disclosed is a transformed cell (a cell model) which can form a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43) that is found in the brain of a patient suffering from a neurodegenerative disease such as FTLD and ALS. The transformed cell is characterized by having, introduced therein, a promoter capable of functioning in a host cell and a mutant TDP-43 gene.

TDP-43-storing cell model

The present invention provides an antibody that specifically binds to an abnormal TDP-43 protein aggregate, an agent comprising the antibody for detecting a TDP-43 proteinopathy lesion, and a method for detecting or diagnosing a TDP-43 proteinopathy lesion by using the antibody.

Antibody binding specifically to TDP-43 aggregate

A power amplifier system suitable for a mobile radio receiver/transmitter is described. A wave form signal to be transmitted is made smooth during its rise and fall times, thereby making it possible to prevent a transmission spectrum from expanding and interfering with the adjacent channels. The power amplifier system compares an envelope signal of an inputted RF signal and that of an RF signal to be outputted, whereby the power amplifier system as a whole provides linear amplification.

Power amplifier system for radio transmitter and method for using the

A radio phone equipment for credit card is adapted to transfer part or a whole of credit card or charge card information read by a card reader as well as a dial number dialed by a key pad to a mobile telecommunication switching office by means of a modem and a transmitter/receiver, and in case of said credit card or charge card being valid, switching, on the basis of a designation on a voice channel transmitted from said mobile telecommunication switching office, or transmitting and receiving frequency to said voice channel to construct a speech channel, and furthermore detecting on-hook of a handset produced upon finishing talking to reset the equipment.

Radiotelephone system adapted to read a credit card

An error control encoding method and a mobile data communication system using the method in a moving body communication system such as mobile telephone for effecting data communication through a fading channel dominated by a burst error, upon receiving data transmitted from the transmitting side on the receiving side, detects any error involved in said received data as a frame error rate involved in block data or a bit error rate in the block data and thereby changes the frame length in response to the detected error rates. The mobile data communication system employs the error control encoding method wherein a frame length employed in the transmitting part is changed in response to the extent of any involved error in the received data detected by the remote receiving part.

Error control encoding system

An error correcting encoding method and a vehicle data communication apparatus based on the same for use in data communication via fading communication channels dominated by burst errors in the data communication among vehicles such as automobiles are disclosed. The error correction encoding method detects, as data sent from a transmitting side is received by a receiving side, any error contained in the received data as a frame error rate of error frames involved in block data or a bit error rate of error bits involved in the block data and selects an error correcting code in response to the frame error rate for encoding. The vehicle data communication apparatus according to the present invention profitably employs the method, and changes an error correcting code to be used on the transmitting side in response to the extent of errors involved in the received data detected by the receiving side of a remote apparatus.

Growing community of inventors

Tokyo, Japan

Haruhiko Akiyama