Basf Aktiengesellschaft

Basf Se Corporation

Evonik Degussa Gmbh

Wintershall Holding Gmbh

Paik Kwang Industrial Co., Ltd.

Basf Aktiencesellschaft

Hartwig Schröder

Oskar Zelder

Burkhard Kröger

Markus Pompejus

Corinna Klopprogge

Gregor Haberhauer

Stefan Haefner

Andrea Herold

Stefan Häfner

Michael Breuer

Rainer Stürmer

Holger Hartmann

Joanna Martyna Krawczyk

Gregory Von Abendroth

Christoph Wittmann

Edzard Scholten

Qingzhao Wang

Shakir Siraj Ratani

Zheyuan Guo

Bernhard Hauer

Hansgeorg Ernst

Thomas Friedrich

R Rogers Yocum

Rajan Hollmann

Thomas A Patterson

Mari Granström

Maria Keβeler

Weol Kyu Jeong

Julia Kristiane Schmidt

Klaus Ditrich

Wolfgang Grabarse

Kai-Uwe Baldenius

Janice G Pero

Daniela Klein

Burkhard Kroger

Matthias Boy

Manfred Ehresmann

Klaus Krämer

Wolfgang Reichert

Esther Dantas Costa

Melanie Bonnekessel

Judith Becker

Andreas Pletsch

Mark K Williams

Hans Gurski

Aline Raddatz

Christian Fleck

Elmar Heinzle

Andrea Molt

Thomas Kaeding

René Stellmacher

Corrinna Klopprogge

Corinna Kolpprogge

Beata Brockmann

Birgit Hoff

Dejana Drew

Jun-Won Kim

Thomas J Lyons

Heung-Shick Lee

Karin Schein

Jakob Weber

Stephan Haefner

Christian Riedele

Byung-Joon Hwang

Heung Shick-Lee

Claudia Isabella Graef

Uwe Ruffer

Torsten Renz

Bernhard Haur

Anna Lange

Benjamin J Lyons

Theron Herman

Jens Kroemer

Anja Knietsch

Eudes De Crecy

Ewa Hughes

Dirk Dägele

Rüdiger Reingruber

Ralf Hoock

The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

Recombinant microorganism for improved production of fine chemicals

The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (Cin g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRin g per liter per hour).

Use of glycerol with limited feed of carbohydrates for fermentation

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Microorganisms for succinic acid production

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.

Modified microorganism with improved biomass separation behaviour

The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.

Microbial succinic acid producers and purification of succinic acid

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Modified microorganism for improved production of fine chemicals on sucrose

The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

Gene cluster for biosynthesis of cornexistin and hydroxycornexistin

The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity or the use of such a polypeptide for producing &#x3b2;-glucans. Furthermore, the present invention relates to methods for producing &#x3b2;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity into a microorganism being able to synthesize &#x3b2;-glucans.

Genetically modified microorganisms capable of producing &#x3b2;-glucans and methods for producing &#x3b2;-glucans

Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans

The present invention relates to a bacterial cell of the genuscomprising a heterologous polypeptide having formate dehydrogenase activity. The present invention also relates to a method of manufacturing succinic acid and the use of the bacterial cell for the manufacture of succinic acid.

Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of succinic acid

The present invention is concerned with bacteria for the production of succinic acid. Specifically, the invention relates to a bacterial cell of the genuscomprising a heterologous polypeptide having isocitrate lyase activity and a heterologous polypeptide having malate synthase activity. Further, the present invention contemplates a polynucleotide comprising a nucleic acid encoding a polypeptide having isocitrate lyase activity and a nucleic acid encoding a polypeptide having malate synthase activity. Finally, the present invention relates to the use of a bacterial cell of the invention for the manufacture of succinic acid.

Bacterial cells having a glyoxylate shunt for the manufacture of succinic acid

The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.

Process for the production of gamma-aminobutyric acid

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Nuβloch, Germany

Hartwig Schröder