Siemens Medical Solutions Usa, Inc.

California Institute of Technology

University of California

Eli Lilly and Company

Fluidigm Corporation

Threshold Pharmaceuticals, Inc.

Hartmuth C Kolb

Joseph C Walsh

Umesh B Gangadharmath

Vani P Mocharla

Dhanalakshmi Kasi

Gang Chen

Arkadij M Elizarov

Kai Chen

Tieming Zhao

Qianwa Liang

Peter J H Scott

Carroll Edward Ball

Jianzhong Zhang

Wei Zhang

Eric Wang

Anjana Sinha

Henry Clifton Padgett

Farhad Karimi

Reza Miraghaie

Anna Katrin Szardenings

Brian A Duclos

Chul Yu

Changhui Liu

Zhiyong Gao

James R Heath

R Michael Van Dam

Thomas Lee Collier

Chunfang Xia

Fanrong Mu

Bing Wang

Sean Ford

Artem Y Lebedev

Todd L Graves

Lawrence Diener

Peter Jh Scott

Stephen R Quake

Hsian-Rong Tseng

Antoine Daridon

Jiang Huang

Michael Van Dam

Michael E Phelps

Paul Wyatt

Keith E Schleiffer

Chung-cheng Lee

Guodong Sui

Ricardo Rodriguez

Robert M Yeh

Robert Michael Van Dam

Vani P Mocharia

Daniel Kurt Cashion

Peter JH Scott

Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

PSMA imaging agents

The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

Substrate based PET imaging agents

A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.

System, device and method for preparing tracers and transferring materials during radiosynthesis

Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.

Formulation, apparatus and method for stabilizing radiopharmaceuticals

A method for synthesizing anF-labeled probe. The method includes a step of eluting an amount ofF with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, theF elutes as anF solution. The method also includes a step of using theF solution to performF-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate theF-labeled probe. In the method, there is no step of drying theF starting from a time when the eluting step is performed and ending at a time when theF-labeling step is performed.

Synthesis of 18F-labeled tracers in hydrous organic solvents

Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.

Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography

Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and &#x3b2;-amyloid peptides are presented herein. The invention also relates to methods of imaging A&#x3b2; and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Imaging agents for detecting neurological disorders

The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

Cyclic azapeptides as integrin markers and methods of using

Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure

Growing community of inventors

Playa Del Rey, CA, United States of America

Hartmuth C Kolb