Technische Universitát Dresden

Other

Merck Patent Gmbh

Biomet Deutschland Gmbh

Nexilis Ag

Technische Universitä{umlaut Over ( )}T Dresden

Friadent Gmbh

Hartmut Worch

Dieter Scharnweber

Wolfgang Pompe

Thomas Hanke

Sascha Heinemann

Sophie Roessler

Curt Kranz

Peter Offermann

Gerald Hoffmann

Michel Dard

René Beutner

Henrike Bersch

Jurgen Hofinger

Martina St&ouml;lzel

Sophie R&ouml;ssler

Michael Thieme

Andreas Sewing

Jan Michael

Bernd Schwenzer

Uwe Köckritz

Gerhilt Schmack

Michael Gelinsky

Susanne Bierbaum

Christiane Heinemann

Hermann Ehrlich

Dieter Schwarnweber

Klaus Becker

The invention relates to novel composite materials based on a collagen matrix mineralized with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralized with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analog, a collagen derivative or a mixture of said collagens.

Composite material consisting of a collagen matrix mineralised with silicate and calcium phosphate phases, method for the production and use thereof

The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.

Growth-inhibited hydroxyapatite, process for its preparation and use

The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibers produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibers.

Osteogenic composite matrix, method for the production thereof and implant and scaffold for tissue engineering provided with a coating formed by said osteogenic composite matrix

A scaffold for tissue culture and cell culture and for producing implant materials, in particular bone, cartilage or skin replacements or extra-corporal organ replacements or for other applications in medicine or biotechnology is made of biocompatible materials. It has at least one base material which is electrostatically flocked with fibers on at least one side. Through the electrostatic flocking the fibers are arranged almost perpendicularly on the surface of the base material and exhibits a high fiber pull-out resistance. The scaffold provides an elastic growth lattice, which is stable against compression, for cell colonization in vitro or the ingrowth of cells in vivo. Implants or implant materials can be produced with the scaffold.

Support material for tissue engineering, for producing implants or implant materials, and an implant produced with the support material

A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5'-terminal or 3&#x2032;-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.

Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object

A biomimetically produced bone-analogous coating, comprising organic and inorganic main constituents, is suitable for coating metallic implant materials of any desired surfaces. The coating comprises a collagen matrix mineralized with calcium phosphate.

Process for the coating for metallic implant materials

A metallic object, having a metallic substrate of a valve metal or a valve metal alloy inclusive of intermetallic phases, and a thin polyphase oxide coating, is disclosed. The polyphase oxide coating has a metal oxide phase and at least one other organic and/or inorganic phase. The polyphase oxide coating is produced by bringing the metallic substrate into contact with an organic and/or inorganic component to be integrated into the polyphase oxide coating such that the inorganic and/or organic phases are present at or in the direct vicinity of the substrate surface and by simultaneously or subsequently anodically polarizing the substrate material in an electrolytic solution.

Metallic object with a thin polyphase oxide coating and process for the manufacture thereof

Process for producing a gradient coating made of calcium phosphate

Growing community of inventors

Dresden, Germany

Hartmut Worch