Hoechst Aktiengesellschaft

Hartmut Voelskow

Susanne Grabley

Gerhard Seibert

Merten Schlingmann

Peter Hammann

Carlo Giani

Wolfgang Raether

Burkhard Sachse

Gerhard Wohner

Axel Zeeck

Sabine Breiding-Mack

Reinhold Keller

Hans-Matthias Deger

Gerhard Kretzschmar

Dieter Duwel

Hans P Kraemer

Edgar Fischer

Joachim Thiem

Johann Then

Gert-Wolfhard Von Rymon Lipinski

Matthias Wiesner

Rainer Buchholz

Rolf Woernle

Hans-Ullrich Hoppe

Dieter Sukatsch

Paul Prave

Erich Luck

Martin Platen

Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.

Streptomyces parvullus DSM 3816

The invention relates to elaiophyline derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.1' are identical or different and represent a radical of the formula II/or III ##STR2## in which R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 have the meanings given. The invention furthermore relates to a process for the preparation of these elaiophyline derivatives and also the use of the lattere as medicaments, in particular as anthelmintically acting medicaments.

Elaiophyline derivatives, compositions containing them and the use

Amycin and its derivatives, a process for their preparation, and their

2-Acetylaminogentisic acid has been isolated from the culture broth after cultivation of a bacterium of the genus Streptomyces. This compound has antibacterial actions against Gram-positive and Gram-negative bacteria.

Gentisic acid derivatives having antibiotic activity

Streptomyces spec. DSM 3813 produces novel compounds with a basic phenoxazinone structure, which have an antifungal and antiviral action and can be used as lipoxygenase inhibitors.

Pharmacological use of phenoxazinones

Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.

Diels-alder adduct from streptazoline and naphthoquinones and its

The strain Streptomyces coelicolor DSM 3030 excretes into the fermentation medium high yields of a bacteriolytic enzyme product which is very active against Gram-positive and Gram-negative bacteria. Preferred fermentation media contain sugar beet molasses and/or calcium ions.

Bacteriolytic enzyme product from streptomyces, a process for its

It is possible by use of a sterilizable fluidized bed fermenter to carry out low-moisture fermentations. Fluidizable granulated microorganisms are used for this fermentation under sterile conditions in the fluidized bed fermenter which is initially operated as a bubble column.

Sterilizable fluidized bed fermenter

L-Phenylalanine can be prepared using microorganisms belonging to the series comprising E. coli, Paracoccus denitrificans, Torula, Rhodotorula or Streptomyces after adaptation to phenylpyruvic acid, by amination with suitable sources of nitrogen. It is advantageous to employ the microorganism in the form of fixed cells.

Process for the preparation of L-phenylalanine

Microbial polysaccharides can be quantitatively precipitated from their aqueous solutions, in particular directly from the fermentation solutions, in an acidic medium in the form of an adduct with a tertiary amine which has a long-chain alkyl radical. It is advantageous to add the amine to the polysaccharide solution and then to carry out the precipitation, in particular by adding the dispersion obtained to an acidic coagulation bath. The adducts are suitable for use as thickeners and for preparing the free polysaccharides.

Microbial polysaccharide amine adducts

Polysaccharides are obtained by fermentation using a mixed culture of several microorganisms, of which at least one also produces a polysaccharide in pure culture, which polysaccharides are suitable as viscosity regulators. A mixed culture of the strains Pseudomonas maltophilia DSM 2130 and Agrobacterium tumefaciens DSM 2128 is particularly suitable.

Microbial polysaccharides, process for their preparation, microorganisms

D-lactic acid is obtained by fermentation of a nutritive medium containing glucose and/or lactose and other usual additives by means of Lactobacillus bulgaricus DSM 2129.

Growing community of inventors

Hattersheim am Main, Germany

Hartmut Voelskow