Ventana Medical Systems, Inc.

Harshal Varangaonkar

Srinivas Chukka

Anindya Sarkar

Jim F Martin

Olcay Sertel

Pascal Bamford

Ellen Suzue

A computer-based specimen analyzer () is configured to detect a level of expression of genes in a cell sample by detecting dots that represent differently stained genes and chromosomes in a cell. The color of the stained genes and the chromosomes is enhanced and filtered to produce a dot mask that defines areas in the image that are genes, chromosomes, or non-genetic material. Metrics are determined for the dots and/or pixels in the image of the cell in areas corresponding to the dots. The metrics are fed to a classifier that separates genes from chromosomes. The results of the classifier are counted to estimate the expression level of genes in the tissue samples.

System and method for detecting gene expression levels in tissue samples

Lab color space silver and red in situ hybridization based techniques for detecting genes in tissue samples

Growing community of inventors

Belmont, CA, United States of America

Harshal Varangaonkar