Zymochem, Inc.

Harshal Akshay Chokhawala

Jonathan C Pistorino

Allison Flynn

Yi-Shu Tai

Jorge Alonso-Gutiérrez

Jonathan Kuchenreuther

Jorge-Alonso Gutierrez

Among other things, the present disclosure provides biosynthesis polypeptides, methods, and non-naturally occurring microbial organisms for preparing various compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, and 2-keto carboxylic acids.

Production of chemicals from renewable sources

Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a Caldehyde and pyruvate to a Cβ-hydroxyketone intermediate through an aldol addition; and b) converting the Cβ-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.

Production of 4,6-dihydroxy-2-oxo-hexanoic acid

Among other things, the present disclosure provides technologies useful as super absorbent polymers.

Growing community of inventors

Castro Valley, CA, United States of America

Harshal Akshay Chokhawala