University of California

Harsh Saigal, Legal Representative

Jogeshwar Mukherjee

Neil Saigal

Contemplated substituted arylpiperazinyl compounds, and most preferablyF-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently withF-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.

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Fresno, CA, United States of America

Harsh Saigal, Legal Representative