Colgate Palmolive Company

University of California

Brigham Young University

Harsh Mahendra Trivedi

Tao Xu

James G Masters

Elizabeth Kelly Gittins

John J Gatzemeyer

Madhusudan Patel

Sharon Kennedy

Ying Yang

Wei Wang

Douglas J Hohlbein

Patrik Johansson

Deborah Ann Peru

Stanislav Jaracz

Eduardo J Jimenez

Michael Prencipe

Zhigang Hao

Lyndsay Schaeffer-Korbylo

Long Pan

Thomas J Boyd

Lynette Anne Zaidel

Paul Joseph Vincenti

Abdul Gaffar

Suman Kumar Chopra

Ravi Subramanyam

Guofeng Xu

Dandan Chen

Davide Miksa

Michael Fitzgerald

Kimberlee Panaligan

Cortney L Worrell

Paul Thomson

Joe Vazquez

Carlo Daep

Virginia Monsul Barnes

Joseph Convery

Laurence Du-Thumm

Shaotang Yuan

Robert D'Ambrogio

Guisheng Pan

Zhiqiang Liu

Susan M Herles

Hrebesh Molly Subhash

David T W Wong

Nora Lin

Jessica Monk

Karthik Sambanthamoorthy

Camille Zenobia

Osman Khalid

Donghui Wu

Gregory Szewczyk

Mahmoud Hassan

Prithwiraj Maitra

Yun Xu

Ammanuel Mehreteab

David F Suriano

Kevin Mark Kinscherf

Carl Myers

LaTonya Kilpatrick-Liverman

Chi-Yuan Cheng

Lisa Manus

Peter R Hilliard

Zeenat F Nabi

Shujiang Cheng

Stacey Lavender

Shashank Vishwanath Potnis

Sayed Ibrahim

Lori H Szeles

Shamim Alam Ansari

Jane Ong

Qiang Wu

Luciana Rinaudi Marron

André M Morgan

Ryan Bradley Cameron

Karolina Elzbieta Kaczor-Urbanowicz

Michael Pacelli

Halyna Siomyk

Ariel Haskel

Melissa Martinetti

Alexander Rickard

Chanda Macias

Jeffrey S Mclean

Zeenat Nabi

Yanan Hu

Ramachandra Shastry

Elizabeth Gittens

Emi Shimizu

Nicola C Partridge

Richard P Darveau

Deon Hines

Derek S Samarian

Gregory Kruse

Salima Hammadi

Gregory Szewzyk

Andre Michelle Morgan

James Gerard Masters

Elizabeth K Gittins

Robert D'ambrogio

Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Oral care composition

In some embodiments, an oral care device includes a flexible base substrate, a power source disposed on the base substrate, and a flexible light source disposed on the base structure or on the power source. The flexible light source is in electrical communication with the power source. Also disclosed are methods of using the same, for example, for whitening the teeth or for treating other conditions in the oral cavity.

Thin, flexible powered oral care device

A system for testing biological samples includes a frame having first and second sides and an aperture extending through the frame from the first side to the second side. First and second covers are attached to the first and second sides of the frame to form a well bounded by the frame, the first cover, and the second cover. An electromagnetic imaging device is used to image the biological sample through the first cover. A method is also conceived, wherein a first fluid is supplied to the well, the first fluid including live cells. A biofilm is grown from the live cells. A second fluid is supplied to the well and the biofilm is imaged using the electromagnetic imaging device.

Apparatus, system, and method for testing biological samples

Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.

Biomarker of gingivitis diagnosis and treatment

An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

Oral health model for high throughput screen and characterization of oral hygiene products

Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject.

Salivary extracellular RNA biomarkers for gingivitis

An oral care implement having conductive protrusions. In one embodiment, the oral care implement includes a handle and a head coupled to the handle. Furthermore, the oral care implement includes a power source. A plurality of conductive protrusions may be electrically coupled to the power source. The plurality of conductive protrusions may include a base proximate the head and a distal end spaced from the head. Furthermore, at least one of the conductive protrusions may taper from the base to the distal end.

Oral care implement with conductive protrusions

Disclosed herein are oral care compositions comprising hemp seed oil and caprylyl glycol. In certain embodiments, the oral care composition optionally further comprises one or more ingredients selected from hyaluronic acid and aloe vera. Methods of making and using the compositions are also provided.

Oral care compositions and methods of use

This invention relates to oral care compositions comprising guanidine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.

Described herein are oral care compositions comprising—in relevant part—an effective amount of inulin. Methods of making and using these compositions are also described.

Oral care compositions

Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; M1F:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.

Biomarkers of neutrophil deregulation as diagnostic for gingivitis

Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individual's oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.

Methods of inducing sIgA and mucin 5b in the oral cavity

An oral care composition including rottlerin in an amount sufficient to reduce a growth of gram-positive bacteria in a mouth treated with the oral care composition.

Oral care composition comprising rottlerin

A computer-implemented method including deriving a health profile of a user from a sample taken from the user and displaying a representation of the health profile on a display, wherein the representation of the health profile includes a list of undesirable oral health characteristics that are detectable from the sample. The representation of the health profile may also include a list of desirable oral health characteristics that are detectable from the sample. Furthermore, a user may select one of the undesirable health characteristics, and in response an indication of historical values associated within he selected one of the undesirable health characteristics may be displayed on the display.

Method of monitoring oral health

Growing community of inventors

Hillsborough, NJ, United States of America

Harsh Mahendra Trivedi