General Electric Company

Orion-Yhtyma Oy

Ge Healthcare Finland Oy

Alko Ltd.

Harry Scheinin

Mika Särkelä

Satu Jääskeläinen

Jaakko Långsjö

Anu Maksimow

Elina Salmi

Risto A Lammintausta

Hanna E Viertiö-Oja

John D Sinclair

Heikki Huikuri

Timo Laitio

Jouko Jalonen

Erkki Kentala

The invention relates to a method and apparatus for monitoring the anesthetic state of a subject. Physiological signal data including EEG and possibly also EMG signal components is acquired from a subject and supplied to a monitoring process configured to derive, based on the said data, a state index indicative of the anesthetic state of the subject. In order to extend the applicability of present-day monitoring processes, the operation of the monitoring process is controlled according to whether at least one drug inducing high frequency EEG signal components is administered to the subject. The presence of the high frequency EEG signal components in the physiological signal data may be detected automatically.

Monitoring of the cerebral state of a subject

The invention relates to a method and apparatus for monitoring the cerebral state of a subject. At least one of a first and second parameters is derived from the physiological signal data obtained from the subject, wherein the first parameter is indicative of the sum of spectral values of the physiological signal data in a first frequency band lying above high frequency EEG activity and the second parameter is indicative of the relative magnitudes of a first sum of k-th order spectral values and a second sum of n-th order spectral values. The second sum is calculated over a frequency band lying above high frequency EEG activity (k&#x3e;2 and n&#x3e;1). A state index is then formed, which is dependent on the at least one parameter and indicative of the cerebral state of the subject. The first and second parameters may be used in the Bispectral Index (BIS&#x2122;) algorithm.

A method and an arrangement for predicting perioperative myocardial ischemia. Heart rate measurements are carried out for example at night- and day-time before the operation to obtain heart rate data. The heart rate data obtained is carried to a device configured to carry out heart rate variability analysis (HRV). Dynamic heart rate variability analysis is carried out by utilizing fractal analysis of the heart rate data and fractal correlation properties obtained from the measured heart rate data are examined to find considerable lowering of the fractal correlation properties during for example night-time when compared to day-time.

Method and arrangement for predicting perioperative myocardial ischemia

A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.

Method for treating alcoholism with nalmefene

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Piispanristi, Finland

Harry Scheinin