Mcneil-ppc, Inc.

Johnson & Johnson Consumer Inc.

Other

Mcneil Ab

Omj Ireland Limited

Chenango Zero LLC

Nicklasson, Fredrik

Harry S Sowden

Joseph R Luber

Leo B Kriksunov

Frank J Bunick

Christopher Szymczak

Christopher E Szymczak

Gerard P McNally

Der-Yang Lee

David W Wynn

Shun Por Li

Shun-Por Li

Martin Thomas

Gerard P Mcnally

Jen-Chi Chen

Gregory E Koll

Oliver Anderson

Bernard F Plantz

Ronni L Robinson

Kenneth E Fuller

William Stuhl

William J Stuhl

Norbert I Berta

Katarina Lindell

Kenneth Day

Jen Chi Chen

Roland Olsson

R Scott Shorts

Timothy P Gilmor

Dan Mcteigue

Gus B Labella

David Wynn

Rolland Olsson

John Hendenstrom

Andreas Hugerth

Fredrik Nicklasson

Narendra Parikh

A dosage form comprising a tablet core and one or more discontinuous coated regions in various configurations on the surface of the dosage form is disclosed. A method for making the dosage form is also disclosed.

Tablets having discontinuous coated regions

A package including a container and a cover sheet, the container having a first section and a second section connected at a breakable joint, the first section includes a well, and the cover sheet is adhered to at least a portion of the first section and at least a portion of the second section and the cover sheet covers the well. Either the first section or the second section is adapted to pivot to assist in breaking the breakable joint in order to separate the first section and the second section, and allow removal of the cover sheet.

Package with a fulcrum and a lever arm

The present invention is directed to a reusable pain relieving treatment device, such as a belt, that comprises one or more conductive members that extend from an inner surface of the device and are capable of transferring heat, cold or vibrations from disposable or reusable packs.

Thermal treatment device

Pharmaceutical package

The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.

Manufacture of tablet in a die utilizing powder blend containing water-containing material

In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.

Method of manufacturing solid dosage form

In one aspect, the present invention features a machine for the production of a solid dosage form wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arranged within the machine such that when RF energy is applied between the first RF electrode and the second RF electrode, the RF energy passes through the portion of the forming cavity adapted to form the dosage form.

Machine for production of solid dosage forms

The present invention features the present invention features a machine for the production of a solid dosage form including: (a) a die platen having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die platen, and a second opening at the surface on the opposite side of the die platen; (b) one or more first forming tools each adapted to move into one of the forming cavities through the first opening of the forming cavity; (c) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the forming cavities through the second opening of the forming cavity; (d) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (e) at least one second RF electrode operably associated with the one or more first forming tools.

Machine for the manufacture of dosage forms utilizing radiofrequency energy

The present invention features a process for making a tablet by (i) compacting a powder blend in a die to form a tablet shape, wherein the powder blend contains a pharmaceutically active agent and a meltable binder and (ii) applying radiofrequency energy to the tablet shape for a sufficient period of time to soften or melt the binder within said tablet shape to form the tablet.

Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder

The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.

Manufacture of lozenge product with radiofrequency

The present invention features the present invention features a tablet including at least one pharmaceutically active ingredient, wherein the shape of said tablet includes at least one major face wherein: (i) the peak penetration resistance at the perimeter of said major face of the tablet is at least about 10% greater than the peak penetration resistance at the center of said major face; and (ii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds, and a machine and method for manufacture of such tablet.

Manufacture of variable density dosage forms utilizing radiofrequency energy

Growing community of inventors

Southampton, PA, United States of America

Harry S Sowden