Pfizer Corporation

Harry R Howard, Jr

Reinhard Sarges

Kevin D Shenk

Brian Thomas O'Neill

Mavis Diane Adam

Marcus Brackeen

John Adams Lowe, Iii

Bertrand Leo Chenard

Fumitaka Ito

Terry J Rosen

John Eugene Macor

David Hepworth

Donald Stuart Middleton

Alan Stobie

Masami Nakane

Kunio Satake

Geoffrey E Gymer

Mark David Andrews

Kishor A Desai

Masaya Ikunaka

Thomas Francis Seeger

Mark Leonard Elliott

Christopher Joseph Schmidt

The invention relates to compounds of formula I 

Phenyl heterocyclyl ethers

Monoamine reuptake inhibitors for treatment of CNS disorders

Biaryl ether derivatives useful as monoamine reuptake inhibitors

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.23, R.sup.24, R.sup.25 and R.sup.26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin (5-HT.sub.1) agonists and antagonists.

Aryl and heteroaryl alkoxynaphthalene derivatives

The present invention relates to diazabicyclic compounds and, specifically, to compounds of the formula ##STR1## wherein A, G, R.sup.1, R.sup.2, R.sup.3, R.sup.4.sub.1 R.sup.5, R.sup.6, and R.sup.7 are as defined in the specification. The compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

Diazabicyclic neurokinin antagonists

Aminomethylene substituted non-aromatic heterocycles and use as

Diazabicyclic neuokinin antagonists

A method of inhibiting cell growth in human small cell lung carcinoma comprising administering to a mammal in need of such treatment a cell growth inhibitory amount of a compound of the formula ##STR1##

Use of naphthalene derivatives in treating lung carcinoma

Substituted benzylamino nitrogen containing non-aromatic heterocycles

Heteroarylamino and heteroarylsulfonamido substituted

Certain 1-substituted 4-(1,2-benzisoxazolyl)-piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.

4-(1,2-benzisoxazolyl)piperidine antipsychotic agents

Heteroaryl piperazine antipsychotic agents

Certain 1-substituted 4-(1,2-benzisoxazolyl)piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.

A series of novel 3-mono(substituted methyl)- and 3,3-di(substituted methyl)-2-oxo-indoline-1-alkanoic acid compounds have been prepared, including their lower alkyl esters and unsubstituted amide derivatives, as well as the base salts of said acids with pharmacologically acceptable cations. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical members include those compounds derived from 2-oxo-indoline-1-acetic acid wherein a 3,4-dichlorobenzyl or 3,4-dichloro-.alpha.-methylbenzyl moiety is substituted at 3-position of the molecule. Preferred member compounds include 3-(3,4-dichlorobenzyl)-2-oxo-indoline-1-acetic acid, 5-chloro-3-(3,4-dichlorobenzyl)-2-oxo-indoline-1-acetic acid, 3-(3,4-dichlorobenzyl)-6-methoxy-2-oxo-indoline-1-acetic acid, 3-(3,4-dichlorobenzyl)-6-hydroxy-2-oxo-indoline-1-acetic acid and 3-(3,4-dichloro-.alpha.-methylbenzyl)-2-oxo-indoline-1-acetic acid. Methods for preparing these compounds from known starting materials are provided.

Indolinone derivatives

Growing community of inventors

Bristol, CT, United States of America

Harry R Howard, Jr