Abbott Laboratories Corporation

Abbvie Inc.

Harry O Spiwek

Sanjay R Chemburkar

Ketan M Patel

Bikshandarkoil A Narayanan

John F Bauer

Azita Saleki-Gerhardt

Philip E Bauer

Kimberly A Allen

Yi-Yin Ku

Daniel A Dickman

Juliette K Busse

James D Ratajczyk

Bhadra Shelat

Hemantkumar H Patel

David P Sawick

Ramesh R Patel

John N Starr

Ketan Patel

A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.

Polymorph of a pharmaceutical

The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

Processes and intermediates for preparing retroviral protease inhibitors

A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante. The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.

Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]-

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Kenosha, WI, United States of America

Harry O Spiwek