Warner-jenkinson Company, Inc.

Harry Meggos

Charles A Signorino

An improved dye composition for use in coating tablets and the like is constituted by a stable, aqueous suspension containing a water-soluble, nontoxic dye, an opacifying agent which may be titanium dioxide or iron oxide an immobilizing agent for immobilizing the dye and preventing it from migrating when applied to a tablet or the like, the immobilizing agent being constituted by a nontoxic metal salt present in an amount of from approximately 0.1 to 10 equivalents of metal per mole of dye, and water. The suspension may also contain a film-forming, water-soluble or water-dispersible edible polymer and a plasticizer. These compositions are used in lieu of lake compositions to produce tablets and the like with uniform, non-mottled coatings.

Dye compositions and methods for film coating tablets and the like

An improved dye composition for use in coating tablets and the like is constituted by a stable, aqueous suspension containing a water-soluble, nontoxic dye, an opacifying agent which may be titanium dioxide or iron oxide all immobilizing agent for immobilizing the dye and preventing it from migrating when applied to a tablet or the like, the immobilizing agent being constituted by a nontoxic metal salt present in an amount of from approximately 0.1 to 10 equivalents of metal per mole of dye, and water. The suspension may also contain a film-forming, water-soluble or water-dispersible edible polymer and a plasticizer. These compositions are used in lieu of lake compositions to produce tablets and the like with uniform, non-mottled coatings.

Improved stable, fluid, aqueous dispersion compositions comprise a pigment, an alkali metal, alkaline earth metal or ammonium salt of a linear aliphatic substituted glycine such as a salt of ethylene diamine tetraacetic acid or nitrilo triacetic acid as a stabilizing agent, and water. The dispersion composition may additionally contain a lower alkanol such as methanol and/or a water soluble plasticizer such as propylene glycol. Coating compositions for use as a film coating for tablets and the like contain the above-described stable, fluid, aqueous dispersion composition, a water soluble plasticizer, a film coating resin, and water. The described fluid, aqueous dispersion compositions have been found to remain stable for extended periods exceeding six months.

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Alton, IL, United States of America

Harry Meggos