Health Research, Inc.

Harry K Slocum

Youcef M Rustum

Karoly Toth

Peter Kanter

Shousong Cao

Farukh Durrani

Arup Bhattacharya

Richard Mazurchuk

Sreenivasulu Chintala

Mukund Seshadri

Rami G Azrak

This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.

Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium

The present invention discloses a method for reducing alopecia and bladder toxicity associated with the anti-cancer agent cyclophosphamide. The method comprises administering to an individual, in need of such a treatment, cyclophosphamide and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.

Method of reducing alopecia and bladder toxicity of cyclophosphamide

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Buffalo, NY, United States of America

Harry K Slocum