British Technology Group USA

Enzon, Inc.

Other

The United States of America As Represented by the Secretary of

United States of America, As Represented by the Secretary of Agriculture

University of Guelph

The United States of America As Represented by the Department of

Btg Usa, Inc.

U.S. Dept. of Agriculture

U.s.a. Dept. of Agriculture

The United States of America As Represented by the Dept. of Agriculture

Harry D Danforth

Michael D Ruff

Susan L Strausberg

Robert L Strausberg

Patricia C Augustine

James W Jacobson

Sharon H Pope

Susan D Wilson

David M Anderson

Russell J McCandliss

Mark L Anderson

Mark C Jenkins

Hyun S Lillehoj

John R Barta

John B Dame

Patricia C Allen

M Aggie Fernando

An immunovariant strain ofwas isolated. Vaccines incorporating the immunovariant strain are effective in eliciting immunological protection against coccidial infection.

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Echinacea dietary supplements are useful adjuvants for live anticoccidial vaccines. Feed supplementation with Echinacea preparations enhances the immune response to such vaccines. in amounts of about 0.1% to 0.5% administered for about two weeks to day-old chicks has been found effective for providing significant weight gain compared to vaccination alone.

Use of echinacea as a feed additive to enhance protection against coccidiosis

A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.

Isolated protein from Eimeria useful as a cross species vaccine

This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Eimeria antigenic composition which elicits antibodies against avian

25 KD coccidial antigen of eimeria tenella

Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b

Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences. The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis. The DNA sequences of the present invention comprise cloned genes or fragments thereof that code on expression for an antigenic protein that activates white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein.

Cloned genes coding for avian coccidiosis antigens which induce a

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Severn, MD, United States of America

Harry D Danforth