Stc.unm

University of Florida Research Foundation, Incorporated

Other

Unm Rainforest Innovations

Harry Craig Pappas

David G Whitten

Eric H Hill

Kirk S Schanze

Thomas S Corbitt

Anand Parthasarathy

Ying Wang

Kiran Bhaskar

Yun Huang

Yue Zhang

Eva Yung Hua Chi

Arjun Thapa

Patrick L Donabedian

Aaron Neumann

Matthew Graus

Rina Sylejmani

Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

P-phenylene ethynylene compounds as bioactive and detection agents

Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a &#x3b2;-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the &#x3b2;-glucan to increase immunogenicity of the fungus.

Treatment and prevention of fungal infections

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R-Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R-Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Conjugated polyelectrolytes and methods of using the same

Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.

Charged singlet-oxygen sensitizers and oppositely-charged surfactants

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R&#x2014;Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R&#x2014;Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Growing community of inventors

Albuquerque, NM, United States of America

Harry Craig Pappas